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- W2083744576 abstract "Abstract A novel type of quinazoline derivatives, which were designed by the combination of quinazoline as the backbone and oxazole scaffold as the substituent, have been synthesized and their biological activities were evaluated for anti‐proliferative activities and EGFR inhibitory potency. Compound 12b demonstrated the most potent inhibitory activity (IC 50 =0.95 µmol/L for EGFR), which could be optimized as a potential EGFR inhibitor in the further study. The structures of the synthesized quinazoline analogs and all intermediates were comfirmed by 1 H and 13 C NMR, 2D NMR spectra, IR spectra and MS spectra." @default.
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- W2083744576 date "2014-06-01" @default.
- W2083744576 modified "2023-09-25" @default.
- W2083744576 title "Design, Synthesis and Bioactivities Evaluation of Novel Quinazoline Analogs Containing Oxazole Units" @default.
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- W2083744576 doi "https://doi.org/10.1002/cjoc.201400271" @default.
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