FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083746078> ?p ?o ?g. }

• W2083746078 endingPage "3852" @default.
• W2083746078 startingPage "3845" @default.
• W2083746078 abstract "Moderate consumption of red wine is associated with a decreased incidence of cardiovascular diseases in populations with relatively high amount of fat in the diet. However, the mechanisms involved in this protective effect are not completely understood. Here we show that moderate consumption of red wine (equivalent to 2 glasses/day in humans) but not ethanol only, improves blood flow recovery by 32% after hindlimb ischemia in hypercholesterolemic ApoE-deficient mice. In ischemic tissues, red wine consumption reduces oxidative stress and increases capillary density by 46%. Endothelial progenitor cells (EPCs) have been shown to have an important role in postnatal neovascularization. We found that the number of EPCs is increased by 60% in ApoE mice exposed to red wine. Moreover, the migratory capacity of EPCs is significantly improved in red wine-drinking mice. The wine used in our study is a cabernet sauvignon from Languedoc-Roussillon, France, which contains a relatively high concentration (4-6 mg/L) of the polyphenolic antioxidant resveratrol. We demonstrate that resveratrol can rescue oxidized low-density lipoprotein (oxLDL)-induced impairment of in vitro angiogenic activities in human umbilical vein endothelial cells (HUVECs). Resveratrol exposure is also associated with increased activation of Akt/eNOS together with a restoration of nitric oxide production in HUVECs exposed to oxLDL. Our study suggests that moderate consumption of red wine improves ischemia-induced neovascularization in high-cholesterol conditions by increasing the number and the functional activities of EPCs and by restoring the Akt-eNOS-NO pathway." @default.
• W2083746078 created "2016-06-24" @default.
• W2083746078 creator A5005639706 @default.
• W2083746078 creator A5007762545 @default.
• W2083746078 creator A5010612645 @default.
• W2083746078 creator A5044149053 @default.
• W2083746078 creator A5075023515 @default.
• W2083746078 creator A5076059173 @default.
• W2083746078 creator A5085345332 @default.
• W2083746078 creator A5014068925 @default.
• W2083746078 date "2007-07-19" @default.
• W2083746078 modified "2023-10-06" @default.
• W2083746078 title "Moderate consumption of red wine (cabernet sauvignon) improves ischemia‐induced neovascularization in ApoE‐deficient mice: effect on endothelial progenitor cells and nitric oxide" @default.
• W2083746078 cites W154610216 @default.
• W2083746078 cites W1938528378 @default.
• W2083746078 cites W1967054449 @default.
• W2083746078 cites W1970132235 @default.
• W2083746078 cites W1980959448 @default.
• W2083746078 cites W1984190184 @default.
• W2083746078 cites W1988786880 @default.
• W2083746078 cites W1994682147 @default.
• W2083746078 cites W1996583908 @default.
• W2083746078 cites W2000292756 @default.
• W2083746078 cites W2005512147 @default.
• W2083746078 cites W2022897423 @default.
• W2083746078 cites W2024838448 @default.
• W2083746078 cites W2028329146 @default.
• W2083746078 cites W2041034845 @default.
• W2083746078 cites W2042761977 @default.
• W2083746078 cites W2053704719 @default.
• W2083746078 cites W2079383900 @default.
• W2083746078 cites W2080836044 @default.
• W2083746078 cites W2081547694 @default.
• W2083746078 cites W2083422332 @default.
• W2083746078 cites W2087221897 @default.
• W2083746078 cites W2088355928 @default.
• W2083746078 cites W2094366418 @default.
• W2083746078 cites W2107689453 @default.
• W2083746078 cites W2112128801 @default.
• W2083746078 cites W2112662230 @default.
• W2083746078 cites W2113502353 @default.
• W2083746078 cites W2125008605 @default.
• W2083746078 cites W2130761693 @default.
• W2083746078 cites W2138463362 @default.
• W2083746078 cites W2141046053 @default.
• W2083746078 cites W2144432599 @default.
• W2083746078 cites W2145639716 @default.
• W2083746078 cites W2153762158 @default.
• W2083746078 cites W2154587590 @default.
• W2083746078 cites W2169386176 @default.
• W2083746078 cites W2171133713 @default.
• W2083746078 doi "https://doi.org/10.1096/fj.06-7491com" @default.
• W2083746078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17641150" @default.
• W2083746078 hasPublicationYear "2007" @default.
• W2083746078 type Work @default.
• W2083746078 sameAs 2083746078 @default.
• W2083746078 citedByCount "76" @default.
• W2083746078 countsByYear W20837460782012 @default.
• W2083746078 countsByYear W20837460782013 @default.
• W2083746078 countsByYear W20837460782014 @default.
• W2083746078 countsByYear W20837460782015 @default.
• W2083746078 countsByYear W20837460782016 @default.
• W2083746078 countsByYear W20837460782017 @default.
• W2083746078 countsByYear W20837460782018 @default.
• W2083746078 countsByYear W20837460782019 @default.
• W2083746078 countsByYear W20837460782020 @default.
• W2083746078 countsByYear W20837460782021 @default.
• W2083746078 countsByYear W20837460782023 @default.
• W2083746078 crossrefType "journal-article" @default.
• W2083746078 hasAuthorship W2083746078A5005639706 @default.
• W2083746078 hasAuthorship W2083746078A5007762545 @default.
• W2083746078 hasAuthorship W2083746078A5010612645 @default.
• W2083746078 hasAuthorship W2083746078A5014068925 @default.
• W2083746078 hasAuthorship W2083746078A5044149053 @default.
• W2083746078 hasAuthorship W2083746078A5075023515 @default.
• W2083746078 hasAuthorship W2083746078A5076059173 @default.
• W2083746078 hasAuthorship W2083746078A5085345332 @default.
• W2083746078 hasConcept C126322002 @default.
• W2083746078 hasConcept C134018914 @default.
• W2083746078 hasConcept C185592680 @default.
• W2083746078 hasConcept C201750760 @default.
• W2083746078 hasConcept C202751555 @default.
• W2083746078 hasConcept C2776151105 @default.
• W2083746078 hasConcept C2776816829 @default.
• W2083746078 hasConcept C2777411675 @default.
• W2083746078 hasConcept C2777622882 @default.
• W2083746078 hasConcept C2778271429 @default.
• W2083746078 hasConcept C2778326061 @default.
• W2083746078 hasConcept C2780394083 @default.
• W2083746078 hasConcept C28328180 @default.
• W2083746078 hasConcept C31903555 @default.
• W2083746078 hasConcept C519581460 @default.
• W2083746078 hasConcept C541997718 @default.
• W2083746078 hasConcept C55493867 @default.
• W2083746078 hasConcept C55952523 @default.
• W2083746078 hasConcept C71924100 @default.
• W2083746078 hasConcept C86803240 @default.
• W2083746078 hasConcept C95444343 @default.

• next