FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083749345> ?p ?o ?g. }

• W2083749345 endingPage "1076" @default.
• W2083749345 startingPage "1064" @default.
• W2083749345 abstract "Group B Streptococcus (GBS) type III is an important agent of life-threatening invasive infections. Albeit the immune system plays a dual role in development and protection against disease, mechanisms leading to an efficient immune response against GBS remain obscure. Mouse bone marrow-derived dendritic cells (DCs) and primary spleen DCs were used to evaluate GBS capacity to modulate the functions of these important antigen-presenting cells. The role of capsular polysaccharide (CPS), one of the most important GBS virulence factors, in bacterial-DC interactions was evaluated by using a non-encapsulated mutant. Phagocytosis assays, confocal and electron microscopy showed that DCs efficiently internalize encapsulated GBS, but the latter possesses strong intracellular survival capacity. GBS devoid of CPS was internalized and killed at higher and faster rates than encapsulated GBS early after infection. Among several cytokines tested, GBS internalization was required for modulation of IL-12, IL-10 and CXCL10 pathways. In contrast, GBS induced DC expression of co-stimulatory molecules in a phagocytosis-independent manner. Finally, the production of pro-inflammatory and Th1 cytokines by GBS-stimulated DCs was differentially modulated by CPS expression, depending on DC origin. Our data suggest multiple mechanisms involved in GBS modulation of DC functions, which were selectively regulated by the presence of CPS." @default.
• W2083749345 created "2016-06-24" @default.
• W2083749345 creator A5019011685 @default.
• W2083749345 creator A5032515537 @default.
• W2083749345 creator A5042038598 @default.
• W2083749345 creator A5052926821 @default.
• W2083749345 creator A5077907328 @default.
• W2083749345 date "2012-10-01" @default.
• W2083749345 modified "2023-10-01" @default.
• W2083749345 title "Role of capsular polysaccharide in Group B Streptococccus interactions with dendritic cells" @default.
• W2083749345 cites W1572509607 @default.
• W2083749345 cites W1614456110 @default.
• W2083749345 cites W1661544713 @default.
• W2083749345 cites W1869217923 @default.
• W2083749345 cites W1881253097 @default.
• W2083749345 cites W1964900947 @default.
• W2083749345 cites W1967415740 @default.
• W2083749345 cites W2004400781 @default.
• W2083749345 cites W2008127373 @default.
• W2083749345 cites W2008588817 @default.
• W2083749345 cites W2016806556 @default.
• W2083749345 cites W2025912300 @default.
• W2083749345 cites W2027552867 @default.
• W2083749345 cites W2032538261 @default.
• W2083749345 cites W2038516698 @default.
• W2083749345 cites W2041687573 @default.
• W2083749345 cites W2047730062 @default.
• W2083749345 cites W2048945411 @default.
• W2083749345 cites W2050087312 @default.
• W2083749345 cites W2057659396 @default.
• W2083749345 cites W2064315633 @default.
• W2083749345 cites W2092235636 @default.
• W2083749345 cites W2095805777 @default.
• W2083749345 cites W2098593412 @default.
• W2083749345 cites W2103063695 @default.
• W2083749345 cites W2107996797 @default.
• W2083749345 cites W2112663666 @default.
• W2083749345 cites W2113295282 @default.
• W2083749345 cites W2115255709 @default.
• W2083749345 cites W2117347683 @default.
• W2083749345 cites W2129202145 @default.
• W2083749345 cites W2130854755 @default.
• W2083749345 cites W2132074768 @default.
• W2083749345 cites W2134530898 @default.
• W2083749345 cites W2135211948 @default.
• W2083749345 cites W2139605495 @default.
• W2083749345 cites W2140229797 @default.
• W2083749345 cites W2146119268 @default.
• W2083749345 cites W2151135806 @default.
• W2083749345 cites W2152950953 @default.
• W2083749345 cites W2153704724 @default.
• W2083749345 cites W2155775702 @default.
• W2083749345 cites W2157443670 @default.
• W2083749345 cites W2161340995 @default.
• W2083749345 cites W2170501593 @default.
• W2083749345 doi "https://doi.org/10.1016/j.micinf.2012.05.015" @default.
• W2083749345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22683668" @default.
• W2083749345 hasPublicationYear "2012" @default.
• W2083749345 type Work @default.
• W2083749345 sameAs 2083749345 @default.
• W2083749345 citedByCount "33" @default.
• W2083749345 countsByYear W20837493452012 @default.
• W2083749345 countsByYear W20837493452013 @default.
• W2083749345 countsByYear W20837493452014 @default.
• W2083749345 countsByYear W20837493452015 @default.
• W2083749345 countsByYear W20837493452016 @default.
• W2083749345 countsByYear W20837493452017 @default.
• W2083749345 countsByYear W20837493452018 @default.
• W2083749345 countsByYear W20837493452019 @default.
• W2083749345 countsByYear W20837493452020 @default.
• W2083749345 countsByYear W20837493452021 @default.
• W2083749345 countsByYear W20837493452022 @default.
• W2083749345 countsByYear W20837493452023 @default.
• W2083749345 crossrefType "journal-article" @default.
• W2083749345 hasAuthorship W2083749345A5019011685 @default.
• W2083749345 hasAuthorship W2083749345A5032515537 @default.
• W2083749345 hasAuthorship W2083749345A5042038598 @default.
• W2083749345 hasAuthorship W2083749345A5052926821 @default.
• W2083749345 hasAuthorship W2083749345A5077907328 @default.
• W2083749345 hasConcept C13373296 @default.
• W2083749345 hasConcept C139770010 @default.
• W2083749345 hasConcept C153726182 @default.
• W2083749345 hasConcept C160448771 @default.
• W2083749345 hasConcept C170493617 @default.
• W2083749345 hasConcept C203014093 @default.
• W2083749345 hasConcept C2778170410 @default.
• W2083749345 hasConcept C55493867 @default.
• W2083749345 hasConcept C86803240 @default.
• W2083749345 hasConcept C8891405 @default.
• W2083749345 hasConcept C89423630 @default.
• W2083749345 hasConcept C95444343 @default.
• W2083749345 hasConceptScore W2083749345C13373296 @default.
• W2083749345 hasConceptScore W2083749345C139770010 @default.
• W2083749345 hasConceptScore W2083749345C153726182 @default.
• W2083749345 hasConceptScore W2083749345C160448771 @default.
• W2083749345 hasConceptScore W2083749345C170493617 @default.
• W2083749345 hasConceptScore W2083749345C203014093 @default.
• W2083749345 hasConceptScore W2083749345C2778170410 @default.

• next