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- W2083749655 endingPage "1192" @default.
- W2083749655 startingPage "1179" @default.
- W2083749655 abstract "A large number of drugs, particularly those with planar chromophores, bind to DNA and consequently interfere with its role as a template in replication and transcription. Many of them form a strong, but reversible, non-covalent complex with the DNA by intercalating between adjacent base-pairs. These drugs are powerful probes of nucleic acid structure and function, and a number of them are clinically useful chemotherapeutic agents. The process of intercalation is considered so crucial that the possible formation of an intercalated complex has been proposed for practically every drug known to bind to DNA (Gale et al., 1981). It is expedient, therefore, when investigating the mode of binding of new drugs at the molecular level to determine at an early stage whether or not intercalaction occurs. In the past, the evidence for classifying a particular drug as an intercalator was often inadequate. Many drugs were tentatively identified as intercalators well before the advent of current methodologies. Even now, some of the tests taken as diagnostic for intercalaction are not strictly adequate. In this review, we examine some of the most commonly employed physico-chetnical probes for intercalation, in order to determine which of them are sufficient and unambiguous." @default.
- W2083749655 created "2016-06-24" @default.
- W2083749655 creator A5065930422 @default.
- W2083749655 creator A5067436439 @default.
- W2083749655 date "1984-01-01" @default.
- W2083749655 modified "2023-09-23" @default.
- W2083749655 title "Physico-chemical probes of intercalation" @default.
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- W2083749655 doi "https://doi.org/10.1016/0020-711x(84)90215-5" @default.
- W2083749655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6397369" @default.
- W2083749655 hasPublicationYear "1984" @default.
- W2083749655 type Work @default.