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- W2083752022 abstract "Abstract The aim of this study was to determine the impact of pitavastatin on low‐density lipoprotein cholesterol (LDL‐C) and lectin‐like oxidized LDL receptor‐1 (LOX‐1) in patients with hypercholesterolemia. Twenty‐five hypercholesterolemic patients (8 male, 17 female; age 66 ± 13, 21–80 years) who had not received anti‐dyslipidemic agents and had LDL‐C levels of more than 160 mg/dL were examined. Biochemical factors were measured at baseline and after treatment with pitavastatin (2 mg/day) for 6 months. Serum levels of LOX‐1 with apolipoprotein B‐100 particle ligand and a soluble form of LOX‐1 (sLOX‐1) were measured by ELISA. All subjects completed the study with no adverse side effects. Total‐C (268 ± 26 vs. 176 ± 17 mg/dL), LDL‐C (182 ± 21 vs. 96 ± 14 mg/dL), and LOX‐1 ligand (867 ± 452 vs. 435 ± 262 ng/mL) were reduced with pitavastatin treatment ( P < 0.0001 for each). Significant decreases in triacylglycerols were noted ( P < 0.0001), but there were no changes in high‐density lipoprotein cholesterol. After 6 months, there were no significant changes in high‐sensitivity CRP or soluble LOX‐1. At baseline, there were no significant correlations between LOX‐1 ligand and either LDL‐C or sLOX‐1. The decrease in LOX‐1 ligand was not correlated with the decrease in LDL‐C, but was correlated with the decrease in sLOX‐1 ( r = 0.47, P < 0.05). In conclusion, pitavastatin therapy had beneficial effects on markers of oxidative stress in hypercholesterolemic subjects. Serum levels of LOX‐1 ligand may be a useful biomarker of the pleiotropic effects of statins." @default.
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- W2083752022 date "2010-03-13" @default.
- W2083752022 modified "2023-09-30" @default.
- W2083752022 title "Pitavastatin Reduces Lectin‐Like Oxidized Low‐Density Lipoprotein Receptor‐1 Ligands in Hypercholesterolemic Humans" @default.
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- W2083752022 doi "https://doi.org/10.1007/s11745-010-3402-7" @default.
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