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• W2083754679 abstract "Aim: To investigate the effect of interleukin-12 p40 gene (IL-12β) 3′-untranslated region polymorphism on the risk of cervical cancer. Methods: DNA was isolated from peripheral blood of 200 patients with cervical cancer and 200 healthy controls. Polymerase chain reaction restriction fragment length polymorphism was used for the detection of IL-12β (1188A/C) gene polymorphism. Results: It was observed that genotypes AC [odds ratio (OR) = 1.80, 95% confidence interval (CI) = 1.17–2.78] and AC + CC (OR = 1.71, 95% CI = 1.11–2.63, P = 0.01) increase the risk of cervical cancer. The strength of the risk in passive smokers with AC and AC + CC genotypes was increased to more than 2.8 times in comparison with a nonsmoker with AA genotype (OR = 2.94, 95% CI = 1.56–5.55, P < 0.001; OR = 2.83, 95% CI = 1.52–5.31, P < 0.001, respectively). Conclusion: This is the first study to provide an evidence for the association of IL-12β (1188A/C) gene polymorphism with the risk of cervical cancer." @default.
• W2083754679 created "2016-06-24" @default.
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• W2083754679 date "2009-10-01" @default.
• W2083754679 modified "2023-10-16" @default.
• W2083754679 title "Interleukin-12 Gene Polymorphism and Cervical Cancer Risk" @default.
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• W2083754679 doi "https://doi.org/10.1097/coc.0b013e318192519a" @default.
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