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- W2083756044 endingPage "1281" @default.
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- W2083756044 abstract "HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4+ T cells, which is indicative of positive selection in the thymus. Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells." @default.
- W2083756044 created "2016-06-24" @default.
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- W2083756044 date "1996-03-01" @default.
- W2083756044 modified "2023-10-11" @default.
- W2083756044 title "Antigen Presentation and T Cell Development in H2-M-Deficient Mice" @default.
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- W2083756044 doi "https://doi.org/10.1126/science.271.5253.1278" @default.
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