FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083760311> ?p ?o ?g. }

• W2083760311 endingPage "52" @default.
• W2083760311 startingPage "44" @default.
• W2083760311 abstract "Summary Memory T‐cell responses are faster and more robust than those of their naïve counterparts. The mechanisms by which memory T cells respond better to subsequent antigenic exposure remain unresolved. A portion of the more rapid response is undoubtedly the result of the increased frequency of antigen‐specific cells. In addition, there are also differences in the cells themselves with respect to their requirements for costimulation and the apparent avidity of the T cells. We used major histocompatibility complex (MHC) class I tetramers to stimulate T cells to focus on the interaction of T‐cell receptor (TCR)/MHC and CD8 in the absence of other molecules that are present on cell surfaces and so contribute to the activation of T cells by undefined mechanisms. Mutated MHC class I tetramers that are unable to engage CD8 were used to investigate the role of CD8 engagement in memory cell activation. Either wild‐type tetramers or tetramers carrying the mutation were used to stimulate both memory and naïve TCR transgenic T cells in vitro . Surprisingly, like naïve cells, memory CD8 + T cells required CD8 engagement for calcium mobilization and optimum proliferation. In contrast, the requirements for cytokine production differed. Unlike naive cells, memory cells were able to produce cytokine in the absence of CD8 engagement. This suggests both a CD8‐dependent pathway for early events and a CD8‐independent pathway for cytokine production in memory cells." @default.
• W2083760311 created "2016-06-24" @default.
• W2083760311 creator A5006208136 @default.
• W2083760311 creator A5007601702 @default.
• W2083760311 creator A5008183954 @default.
• W2083760311 creator A5044066096 @default.
• W2083760311 date "2004-12-16" @default.
• W2083760311 modified "2023-10-15" @default.
• W2083760311 title "Memory CD8+ T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production" @default.
• W2083760311 cites W1481172479 @default.
• W2083760311 cites W1523147669 @default.
• W2083760311 cites W1592421151 @default.
• W2083760311 cites W1910447160 @default.
• W2083760311 cites W1966038880 @default.
• W2083760311 cites W1968611188 @default.
• W2083760311 cites W1970735079 @default.
• W2083760311 cites W1974155752 @default.
• W2083760311 cites W1985402375 @default.
• W2083760311 cites W1990694172 @default.
• W2083760311 cites W1998921946 @default.
• W2083760311 cites W1999535057 @default.
• W2083760311 cites W2007906437 @default.
• W2083760311 cites W2008182583 @default.
• W2083760311 cites W2012986510 @default.
• W2083760311 cites W2024441858 @default.
• W2083760311 cites W2029128444 @default.
• W2083760311 cites W2029154862 @default.
• W2083760311 cites W2031482359 @default.
• W2083760311 cites W2049491684 @default.
• W2083760311 cites W2055271950 @default.
• W2083760311 cites W2060165194 @default.
• W2083760311 cites W2063880503 @default.
• W2083760311 cites W2067069532 @default.
• W2083760311 cites W2070530924 @default.
• W2083760311 cites W2078547056 @default.
• W2083760311 cites W2080103171 @default.
• W2083760311 cites W2094213517 @default.
• W2083760311 cites W2098642868 @default.
• W2083760311 cites W2102551327 @default.
• W2083760311 cites W2107545472 @default.
• W2083760311 cites W2108861854 @default.
• W2083760311 cites W2109486770 @default.
• W2083760311 cites W2113148417 @default.
• W2083760311 cites W2114675843 @default.
• W2083760311 cites W2119856645 @default.
• W2083760311 cites W2121931877 @default.
• W2083760311 cites W2129134079 @default.
• W2083760311 cites W2131991790 @default.
• W2083760311 cites W2132224394 @default.
• W2083760311 cites W2149014514 @default.
• W2083760311 cites W2165051352 @default.
• W2083760311 cites W2166313015 @default.
• W2083760311 cites W4313347992 @default.
• W2083760311 doi "https://doi.org/10.1111/j.1365-2567.2004.02070.x" @default.
• W2083760311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782059" @default.
• W2083760311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15606794" @default.
• W2083760311 hasPublicationYear "2004" @default.
• W2083760311 type Work @default.
• W2083760311 sameAs 2083760311 @default.
• W2083760311 citedByCount "9" @default.
• W2083760311 countsByYear W20837603112012 @default.
• W2083760311 countsByYear W20837603112013 @default.
• W2083760311 countsByYear W20837603112015 @default.
• W2083760311 crossrefType "journal-article" @default.
• W2083760311 hasAuthorship W2083760311A5006208136 @default.
• W2083760311 hasAuthorship W2083760311A5007601702 @default.
• W2083760311 hasAuthorship W2083760311A5008183954 @default.
• W2083760311 hasAuthorship W2083760311A5044066096 @default.
• W2083760311 hasBestOaLocation W20837603112 @default.
• W2083760311 hasConcept C129374314 @default.
• W2083760311 hasConcept C147483822 @default.
• W2083760311 hasConcept C148125776 @default.
• W2083760311 hasConcept C154317977 @default.
• W2083760311 hasConcept C167672396 @default.
• W2083760311 hasConcept C170627219 @default.
• W2083760311 hasConcept C19317047 @default.
• W2083760311 hasConcept C202751555 @default.
• W2083760311 hasConcept C203014093 @default.
• W2083760311 hasConcept C207936829 @default.
• W2083760311 hasConcept C2776090121 @default.
• W2083760311 hasConcept C2778690821 @default.
• W2083760311 hasConcept C55493867 @default.
• W2083760311 hasConcept C67662055 @default.
• W2083760311 hasConcept C86803240 @default.
• W2083760311 hasConcept C8891405 @default.
• W2083760311 hasConcept C95444343 @default.
• W2083760311 hasConceptScore W2083760311C129374314 @default.
• W2083760311 hasConceptScore W2083760311C147483822 @default.
• W2083760311 hasConceptScore W2083760311C148125776 @default.
• W2083760311 hasConceptScore W2083760311C154317977 @default.
• W2083760311 hasConceptScore W2083760311C167672396 @default.
• W2083760311 hasConceptScore W2083760311C170627219 @default.
• W2083760311 hasConceptScore W2083760311C19317047 @default.
• W2083760311 hasConceptScore W2083760311C202751555 @default.
• W2083760311 hasConceptScore W2083760311C203014093 @default.
• W2083760311 hasConceptScore W2083760311C207936829 @default.
• W2083760311 hasConceptScore W2083760311C2776090121 @default.
• W2083760311 hasConceptScore W2083760311C2778690821 @default.

• next