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• W2083761268 abstract "Using semi-micro methods, plasma renin activity (PRA) and plasma aldosterone concentration (PA) were measured concurrently in 79 healthy children aged 1 month to 15 years to establish a reference range. PRA and PA varied inversely with age. Eleven children with renal hypertension had higher PRA and PA than age-matched controls. In contrast, PRA was much greater in 38 saline-depleted children. PA was not uniformly increased in this group and was within the normal range in children with adrenal diseases compared with the high values seen in other salt-wasting states. The findings emphasise the need to relate data from patients to age-matched control values before attempting interpretation and suggest that sodium depletion is a more potent stimulator of renin-aldosterone release than renovascular disease or renal scarring in children. Plasma renin-aldosterone profiles were also valuable in discriminating between renal and adrenal causes of salt loss in childhood." @default.
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• W2083761268 date "1975-11-08" @default.
• W2083761268 modified "2023-10-10" @default.
• W2083761268 title "Plasma renin activity and aldosterone concentration in children." @default.
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• W2083761268 doi "https://doi.org/10.1136/bmj.4.5992.316" @default.
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