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• W2083778257 abstract "It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D magnetic resonance imaging of five affected family members, 10 non-affected relatives, and 15 unrelated matched controls. Affected and non-affected relatives were characterized by larger left amygdalae (18%, p=0.030), smaller right hippocampus (up to 18%, p<0.0005), and reduced hippocampal asymmetry (p<0.001) than controls. Abnormal, albeit non significant, positive correlations of MTL volumes with age were observed, with the exception of smaller volume of the left hippocampus with advancing age (r=-0.76) in the affected relatives. These data add to the evidence that abnormal medial temporal structures may constitute an endophenotype for affective disorders." @default.
• W2083778257 created "2016-06-24" @default.
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• W2083778257 date "2010-01-01" @default.
• W2083778257 modified "2023-10-05" @default.
• W2083778257 title "Clinical and medial temporal features in a family with mood disorders" @default.
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• W2083778257 doi "https://doi.org/10.1016/j.neulet.2009.10.067" @default.
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