FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083786610> ?p ?o ?g. }

• W2083786610 endingPage "1188" @default.
• W2083786610 startingPage "1177" @default.
• W2083786610 abstract "Abstract Background There is controversy regarding the effect of alcohol beverage intake in vascular vasodilatory function in peripheral arteries. The effects of beer intake in coronary vasodilation remain unknown. We investigated whether regular beer intake (alcohol and alcohol‐free) protects against hypercholesterolaemia‐induced coronary endothelial dysfunction and the mechanisms behind this effect. Materials and methods Pigs were fed 10 days: (i) a Western‐type hypercholesterolaemic diet (WD); (ii) WD+low‐dose beer (12·5 g alcohol/day); (iii) WD+moderate‐dose beer (25 g alcohol/day); or (iv) WD+moderate‐dose alcohol‐free‐beer (0·0 g alcohol/day). Coronary responses to endothelium‐dependent vasoactive drugs (acetylcholine: receptor mediated; calcium ionophore‐A23189: nonreceptor mediated), endothelium‐independent vasoactive drug (SNP) and L‐NMMA (NOS‐antagonist) were evaluated in the LAD coronary artery by flow Doppler. Coronary Akt/ eNOS activation, MCP‐1 expression, oxidative DNA damage and superoxide production were assessed. Lipid profile, lipoproteins resistance to oxidation and urinary isoxanthohumol concentration were evaluated. Results Alcoholic and nonalcoholic beer intake prevented WD‐induced impairment of receptor‐ and non‐receptor‐operated endothelial‐dependent coronary vasodilation. All animals displayed a similar vasodilatory response to SNP and L‐NMMA blunted all endothelial‐dependent vasorelaxation responses. Haemodynamic parameters remained unchanged. Coronary arteries showed lower DNA damage and increased Akt/ eNOS axis activation in beer‐fed animals. Animals taking beer showed HDL with higher antioxidant capacity, higher LDL resistance to oxidation and increased isoxanthohumol levels. Weight, lipids levels, liver enzymes and MCP‐1 expression were not affected by beer intake. Conclusions Non‐alcoholic‐related beer components protect against hyperlipemia‐induced coronary endothelial dysfunction by counteracting vascular oxidative damage and preserving the Akt/ eNOS pathway. Light‐to‐moderate beer consumption prevents and/or reduces the endothelial dysfunction associated with cardiovascular risk factors." @default.
• W2083786610 created "2016-06-24" @default.
• W2083786610 creator A5004801541 @default.
• W2083786610 creator A5008138575 @default.
• W2083786610 creator A5026504610 @default.
• W2083786610 creator A5037636014 @default.
• W2083786610 creator A5041995003 @default.
• W2083786610 creator A5081257789 @default.
• W2083786610 date "2014-12-01" @default.
• W2083786610 modified "2023-10-14" @default.
• W2083786610 title "Beer elicits vasculoprotective effects through Akt/eNOS activation" @default.
• W2083786610 cites W102080802 @default.
• W2083786610 cites W179136504 @default.
• W2083786610 cites W1931998965 @default.
• W2083786610 cites W1967382593 @default.
• W2083786610 cites W1969728057 @default.
• W2083786610 cites W1975258993 @default.
• W2083786610 cites W1977557850 @default.
• W2083786610 cites W1981595730 @default.
• W2083786610 cites W1988908717 @default.
• W2083786610 cites W1996105671 @default.
• W2083786610 cites W2001008996 @default.
• W2083786610 cites W2026779122 @default.
• W2083786610 cites W2027358064 @default.
• W2083786610 cites W2043081463 @default.
• W2083786610 cites W2046561887 @default.
• W2083786610 cites W2047257503 @default.
• W2083786610 cites W2051961864 @default.
• W2083786610 cites W2057116025 @default.
• W2083786610 cites W2066188137 @default.
• W2083786610 cites W2071850731 @default.
• W2083786610 cites W2072157574 @default.
• W2083786610 cites W2074700964 @default.
• W2083786610 cites W2077535449 @default.
• W2083786610 cites W2079383900 @default.
• W2083786610 cites W2083481797 @default.
• W2083786610 cites W2096913256 @default.
• W2083786610 cites W2104174737 @default.
• W2083786610 cites W2105039169 @default.
• W2083786610 cites W2109129984 @default.
• W2083786610 cites W2116957504 @default.
• W2083786610 cites W2119431917 @default.
• W2083786610 cites W2120100788 @default.
• W2083786610 cites W2123254488 @default.
• W2083786610 cites W2128516271 @default.
• W2083786610 cites W2129967699 @default.
• W2083786610 cites W2130129695 @default.
• W2083786610 cites W2134385932 @default.
• W2083786610 cites W2145675902 @default.
• W2083786610 cites W2145899271 @default.
• W2083786610 cites W2147665626 @default.
• W2083786610 cites W2148078723 @default.
• W2083786610 cites W2155375084 @default.
• W2083786610 cites W2160678120 @default.
• W2083786610 cites W2167866149 @default.
• W2083786610 cites W2169997452 @default.
• W2083786610 doi "https://doi.org/10.1111/eci.12352" @default.
• W2083786610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25323945" @default.
• W2083786610 hasPublicationYear "2014" @default.
• W2083786610 type Work @default.
• W2083786610 sameAs 2083786610 @default.
• W2083786610 citedByCount "18" @default.
• W2083786610 countsByYear W20837866102016 @default.
• W2083786610 countsByYear W20837866102017 @default.
• W2083786610 countsByYear W20837866102018 @default.
• W2083786610 countsByYear W20837866102019 @default.
• W2083786610 countsByYear W20837866102020 @default.
• W2083786610 countsByYear W20837866102022 @default.
• W2083786610 countsByYear W20837866102023 @default.
• W2083786610 crossrefType "journal-article" @default.
• W2083786610 hasAuthorship W2083786610A5004801541 @default.
• W2083786610 hasAuthorship W2083786610A5008138575 @default.
• W2083786610 hasAuthorship W2083786610A5026504610 @default.
• W2083786610 hasAuthorship W2083786610A5037636014 @default.
• W2083786610 hasAuthorship W2083786610A5041995003 @default.
• W2083786610 hasAuthorship W2083786610A5081257789 @default.
• W2083786610 hasConcept C120770815 @default.
• W2083786610 hasConcept C126322002 @default.
• W2083786610 hasConcept C134018914 @default.
• W2083786610 hasConcept C185592680 @default.
• W2083786610 hasConcept C2776992346 @default.
• W2083786610 hasConcept C2777622882 @default.
• W2083786610 hasConcept C2778326061 @default.
• W2083786610 hasConcept C2780972559 @default.
• W2083786610 hasConcept C519581460 @default.
• W2083786610 hasConcept C71924100 @default.
• W2083786610 hasConceptScore W2083786610C120770815 @default.
• W2083786610 hasConceptScore W2083786610C126322002 @default.
• W2083786610 hasConceptScore W2083786610C134018914 @default.
• W2083786610 hasConceptScore W2083786610C185592680 @default.
• W2083786610 hasConceptScore W2083786610C2776992346 @default.
• W2083786610 hasConceptScore W2083786610C2777622882 @default.
• W2083786610 hasConceptScore W2083786610C2778326061 @default.
• W2083786610 hasConceptScore W2083786610C2780972559 @default.
• W2083786610 hasConceptScore W2083786610C519581460 @default.
• W2083786610 hasConceptScore W2083786610C71924100 @default.
• W2083786610 hasIssue "12" @default.
• W2083786610 hasLocation W20837866101 @default.

• next