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- W2083788921 abstract "Although successful needle-free DNA vaccination has been described on several occasions, the true benefit of this delivery technology over needle-based injections for DNA vaccination of dogs has not yet been documented. We conducted a side-by-side comparison of needle-free transdermal plasmid delivery vs. intramuscular vs. intradermal needle-based delivery of the same plasmid in dogs. Our data confirmed the importance of the route of plasmid delivery and further established the unique potential of needle-free transdermal plasmid delivery to elicit strong antigen-specific, hTyr-specific IFNgamma T in the dog. Further, this study demonstrated that properly enabled DNA vaccination has the potential to trigger very significant cell-based immune responses in dogs, establishing needle-free transdermal plasmid delivery as a critical technology for successful immunotherapy of cancer and/or chronic infectious diseases in companion animal medicine." @default.
- W2083788921 created "2016-06-24" @default.
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- W2083788921 date "2008-04-01" @default.
- W2083788921 modified "2023-10-14" @default.
- W2083788921 title "Superiority of needle-free transdermal plasmid delivery for the induction of antigen-specific IFNγ T cell responses in the dog" @default.
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- W2083788921 doi "https://doi.org/10.1016/j.vaccine.2008.01.059" @default.
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