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• W2083809612 endingPage "e0117226" @default.
• W2083809612 startingPage "e0117226" @default.
• W2083809612 abstract "Few studies have been undertaken to assess the possible effects of bisphenol A (BPA) on the reproductive hormone balance in animals or humans with often contradictory results. We investigated possible direct endocrine disruption by BPA of the fetal testes of 2 rat strains (14.5–17.5 days post-coitum) and humans (8–12 gestational weeks) and under different culture conditions. BPA concentrations of 10-8M and 10-5M for 72h reduced testosterone production by the Sprague-Dawley fetal rat testes, while only 10-5M suppressed it in the Wistar strain. The suppressive effects at 10-5M were seen as early as 24h and 48h in both strains. BPA at 10-7-10-5M for 72h suppressed the levels of fetal rat Leydig cell insulin-like factor 3 (INSL3). BPA exposure at 10-8M, 10-7M, and 10-5M for 72h inhibited testosterone production in fetal human testes. For the lowest doses, the effects observed occurred only when no gonadotrophin was added to the culture media and were associated with a poorly preserved testicular morphology. We concluded that (i) BPA can display anti-androgenic effects both in rat and human fetal testes; (ii) it is essential to ascertain that the divergent effects of endocrine disruptors between species in vitro do not result from the culture conditions used, and/or the rodent strain selected; (iii) the optimization of each in vitro assay for a given species should be a major objective rather than the search of an hypothetical trans-species consensual model-system, as the organization of the testis is intrinsically different between mammalian species; (iv) due to the uncertainty existing on the internal exposure of the human fetal testis to BPA, and the insufficient number of epidemiological studies on the endocrine disruptive effects of BPA, caution should be taken in the extrapolation of our present results to the human reproductive health after fetal exposure to BPA." @default.
• W2083809612 created "2016-06-24" @default.
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• W2083809612 date "2015-02-23" @default.
• W2083809612 modified "2023-10-13" @default.
• W2083809612 title "An Investigation of the Endocrine-Disruptive Effects of Bisphenol A in Human and Rat Fetal Testes" @default.
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• W2083809612 doi "https://doi.org/10.1371/journal.pone.0117226" @default.
• W2083809612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4338204" @default.
• W2083809612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25706302" @default.
• W2083809612 hasPublicationYear "2015" @default.
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