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• W2083811621 abstract "Cyclophosphamide (Cyc) is known to cause ovotoxicity and infertility in women. Our aim is to investigate the possible ovotoxic effects of Cyc and possible antioxidant and protective effects of blue-green algae, Spirulina (Sp), in rat ovaries. Eighteen rats were given: group I (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn></mml:math>, control); group II (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn></mml:math>, CP), a single dose Cyc; group III (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn></mml:math>, Sp+Cyc), 7 days Sp+single dose Cyc. Tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) activities are assessed biochemically. Normal and atretic primordial and primary follicle counts for all sections obtained for each ovary are calculated. Mean number of follicle counts for each group are compared. In Sp+Cyc group, tissue MDA levels were significantly lower than those in the CP and higher than those in the C group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mtext>CP</mml:mtext><mml:mo>></mml:mo><mml:mtext>Sp</mml:mtext></mml:mrow></mml:math>+<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mtext>Cyc</mml:mtext><mml:mo>></mml:mo><mml:mtext>C</mml:mtext></mml:mrow></mml:math>). Tissue SOD activity was significantly higher in Sp+Cyc group than that in the CP group and lower than that in the C group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mtext>C</mml:mtext><mml:mo>></mml:mo><mml:mtext>Sp</mml:mtext></mml:mrow></mml:math>+<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:mtext>Cyc</mml:mtext><mml:mo>></mml:mo><mml:mtext>C</mml:mtext></mml:mrow></mml:math>). No statistically significant difference was found between the ovarian CAT activities in any group. Histomorphometrically, there was also no significant difference between the mean numbers of normal and atretic small follicle counts. Our results suggest that single dose Cyc has adverse effects on oxidant status of the ovaries and Sp has protective effects in Cyc-induced ovotoxicity." @default.
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• W2083811621 date "2013-01-01" @default.
• W2083811621 modified "2023-10-16" @default.
• W2083811621 title "Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats: Biochemical and Histomorphometric Evaluation of the Ovary" @default.
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• W2083811621 doi "https://doi.org/10.1155/2013/764262" @default.
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