Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083838178> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2083838178 endingPage "131" @default.
- W2083838178 startingPage "123" @default.
- W2083838178 abstract "Investigate the use of solution NMR spectroscopy to evaluate whether the general ΔpKa rule is valid in organic solvents. Such information may be useful in evaluation of acid–base reactions and solvent selection for salt formation. 1H NMR chemical shift changes in model bases during titration with acids, and separately, on the addition of acids at a molar ratio of 1:1 were determined in water, dimethyl sulfoxide, and methanol. The effect of acid strength on the fraction of ionized base was examined. 1H NMR chemical shift changes indicated protonation (in situ salt formation). Different media affected the observed chemical shift changes. In all media investigated the data followed the ΔpKa (base–acid) general rule, that the pKa value of the acids should be 2–3 units lower than the pKa of the base to ensure proton transfer. The addition of water into organic solvents increased the fraction of ionized base. Protonation, as measured by chemical shift changes using solution NMR spectroscopy, provided novel insight on potential salt formation in different media. Even though pKa values change with the solvent, the general ΔpKa rule can be applied in different solvent systems. Solution NMR spectroscopy appears to be a useful tool to evaluate salt formation reaction and process control in different solvent systems." @default.
- W2083838178 created "2016-06-24" @default.
- W2083838178 creator A5081927504 @default.
- W2083838178 creator A5089510416 @default.
- W2083838178 creator A5090167841 @default.
- W2083838178 date "2013-05-01" @default.
- W2083838178 modified "2023-09-25" @default.
- W2083838178 title "Quantification of protonation in organic solvents using solution NMR spectroscopy: Implication in salt formation" @default.
- W2083838178 cites W1969032640 @default.
- W2083838178 cites W1979220369 @default.
- W2083838178 cites W1996234429 @default.
- W2083838178 cites W1996336227 @default.
- W2083838178 cites W1999861739 @default.
- W2083838178 cites W2008985352 @default.
- W2083838178 cites W2011134011 @default.
- W2083838178 cites W2024865483 @default.
- W2083838178 cites W2028454122 @default.
- W2083838178 cites W2034590718 @default.
- W2083838178 cites W2035939818 @default.
- W2083838178 cites W2036977240 @default.
- W2083838178 cites W2048322679 @default.
- W2083838178 cites W2073586463 @default.
- W2083838178 cites W2078130861 @default.
- W2083838178 cites W2080360315 @default.
- W2083838178 cites W2128103808 @default.
- W2083838178 cites W2138252023 @default.
- W2083838178 cites W2155604981 @default.
- W2083838178 doi "https://doi.org/10.1016/j.ijpharm.2013.03.040" @default.
- W2083838178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23541876" @default.
- W2083838178 hasPublicationYear "2013" @default.
- W2083838178 type Work @default.
- W2083838178 sameAs 2083838178 @default.
- W2083838178 citedByCount "10" @default.
- W2083838178 countsByYear W20838381782014 @default.
- W2083838178 countsByYear W20838381782016 @default.
- W2083838178 countsByYear W20838381782017 @default.
- W2083838178 countsByYear W20838381782018 @default.
- W2083838178 countsByYear W20838381782019 @default.
- W2083838178 countsByYear W20838381782022 @default.
- W2083838178 countsByYear W20838381782023 @default.
- W2083838178 crossrefType "journal-article" @default.
- W2083838178 hasAuthorship W2083838178A5081927504 @default.
- W2083838178 hasAuthorship W2083838178A5089510416 @default.
- W2083838178 hasAuthorship W2083838178A5090167841 @default.
- W2083838178 hasConcept C103319777 @default.
- W2083838178 hasConcept C111429119 @default.
- W2083838178 hasConcept C132439834 @default.
- W2083838178 hasConcept C134306372 @default.
- W2083838178 hasConcept C145148216 @default.
- W2083838178 hasConcept C147789679 @default.
- W2083838178 hasConcept C154283680 @default.
- W2083838178 hasConcept C178790620 @default.
- W2083838178 hasConcept C179104552 @default.
- W2083838178 hasConcept C184866935 @default.
- W2083838178 hasConcept C185592680 @default.
- W2083838178 hasConcept C2776371256 @default.
- W2083838178 hasConcept C2780471494 @default.
- W2083838178 hasConcept C30095370 @default.
- W2083838178 hasConcept C33923547 @default.
- W2083838178 hasConcept C42058472 @default.
- W2083838178 hasConcept C66974803 @default.
- W2083838178 hasConceptScore W2083838178C103319777 @default.
- W2083838178 hasConceptScore W2083838178C111429119 @default.
- W2083838178 hasConceptScore W2083838178C132439834 @default.
- W2083838178 hasConceptScore W2083838178C134306372 @default.
- W2083838178 hasConceptScore W2083838178C145148216 @default.
- W2083838178 hasConceptScore W2083838178C147789679 @default.
- W2083838178 hasConceptScore W2083838178C154283680 @default.
- W2083838178 hasConceptScore W2083838178C178790620 @default.
- W2083838178 hasConceptScore W2083838178C179104552 @default.
- W2083838178 hasConceptScore W2083838178C184866935 @default.
- W2083838178 hasConceptScore W2083838178C185592680 @default.
- W2083838178 hasConceptScore W2083838178C2776371256 @default.
- W2083838178 hasConceptScore W2083838178C2780471494 @default.
- W2083838178 hasConceptScore W2083838178C30095370 @default.
- W2083838178 hasConceptScore W2083838178C33923547 @default.
- W2083838178 hasConceptScore W2083838178C42058472 @default.
- W2083838178 hasConceptScore W2083838178C66974803 @default.
- W2083838178 hasIssue "1" @default.
- W2083838178 hasLocation W20838381781 @default.
- W2083838178 hasLocation W20838381782 @default.
- W2083838178 hasOpenAccess W2083838178 @default.
- W2083838178 hasPrimaryLocation W20838381781 @default.
- W2083838178 hasRelatedWork W1966968176 @default.
- W2083838178 hasRelatedWork W1994165769 @default.
- W2083838178 hasRelatedWork W2035939818 @default.
- W2083838178 hasRelatedWork W2037614597 @default.
- W2083838178 hasRelatedWork W2092467094 @default.
- W2083838178 hasRelatedWork W2094909260 @default.
- W2083838178 hasRelatedWork W2482327377 @default.
- W2083838178 hasRelatedWork W2498129948 @default.
- W2083838178 hasRelatedWork W2949854384 @default.
- W2083838178 hasRelatedWork W3192373579 @default.
- W2083838178 hasVolume "448" @default.
- W2083838178 isParatext "false" @default.
- W2083838178 isRetracted "false" @default.
- W2083838178 magId "2083838178" @default.
- W2083838178 workType "article" @default.