Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083840551> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2083840551 endingPage "1474" @default.
- W2083840551 startingPage "1463" @default.
- W2083840551 abstract "P2Y2 receptor agonists are a new class of compounds that are being evaluated as a treatment for the pulmonary manifestations of Cystic Fibrosis (CF). Results of preclinical research suggest that these compounds inhibit sodium absorption, restore chloride conductance and rehydrate the CF airway surface. In addition, P2Y2 receptor agonists have been shown to enhance ciliary beat frequency and increase mucociliary clearance in animals and subjects with impaired mucociliary clearance. The normalization of airway surface liquid and enhancement of lung clearance is expected to provide a clinical benefit to CF patients. A number of P2Y2 agonist compounds have been evaluated in healthy subjects and patients with CF. Most recently, INS37217, a metabolically stable and potent P2Y2 agonist has been developed and studies have shown it to be well-tolerated when given via inhalation. This compound is currently being evaluated in children and adults with CF lung disease." @default.
- W2083840551 created "2016-06-24" @default.
- W2083840551 creator A5020088940 @default.
- W2083840551 creator A5049471715 @default.
- W2083840551 creator A5057855805 @default.
- W2083840551 creator A5062606600 @default.
- W2083840551 date "2002-12-01" @default.
- W2083840551 modified "2023-10-18" @default.
- W2083840551 title "Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease" @default.
- W2083840551 cites W1796144808 @default.
- W2083840551 cites W1975392354 @default.
- W2083840551 cites W1984709649 @default.
- W2083840551 cites W2010844072 @default.
- W2083840551 cites W2013399862 @default.
- W2083840551 cites W2022634662 @default.
- W2083840551 cites W2061559509 @default.
- W2083840551 cites W2076205950 @default.
- W2083840551 cites W2101273248 @default.
- W2083840551 cites W2116985644 @default.
- W2083840551 cites W2117300004 @default.
- W2083840551 cites W2144712242 @default.
- W2083840551 cites W2149658463 @default.
- W2083840551 cites W2317332612 @default.
- W2083840551 cites W2333398204 @default.
- W2083840551 cites W2338243080 @default.
- W2083840551 cites W34123101 @default.
- W2083840551 cites W4233594215 @default.
- W2083840551 cites W4236247973 @default.
- W2083840551 doi "https://doi.org/10.1016/s0169-409x(02)00154-0" @default.
- W2083840551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12458155" @default.
- W2083840551 hasPublicationYear "2002" @default.
- W2083840551 type Work @default.
- W2083840551 sameAs 2083840551 @default.
- W2083840551 citedByCount "71" @default.
- W2083840551 countsByYear W20838405512012 @default.
- W2083840551 countsByYear W20838405512013 @default.
- W2083840551 countsByYear W20838405512014 @default.
- W2083840551 countsByYear W20838405512015 @default.
- W2083840551 countsByYear W20838405512017 @default.
- W2083840551 countsByYear W20838405512018 @default.
- W2083840551 countsByYear W20838405512019 @default.
- W2083840551 countsByYear W20838405512020 @default.
- W2083840551 countsByYear W20838405512021 @default.
- W2083840551 countsByYear W20838405512022 @default.
- W2083840551 countsByYear W20838405512023 @default.
- W2083840551 crossrefType "journal-article" @default.
- W2083840551 hasAuthorship W2083840551A5020088940 @default.
- W2083840551 hasAuthorship W2083840551A5049471715 @default.
- W2083840551 hasAuthorship W2083840551A5057855805 @default.
- W2083840551 hasAuthorship W2083840551A5062606600 @default.
- W2083840551 hasConcept C105922876 @default.
- W2083840551 hasConcept C114682108 @default.
- W2083840551 hasConcept C126322002 @default.
- W2083840551 hasConcept C170493617 @default.
- W2083840551 hasConcept C203014093 @default.
- W2083840551 hasConcept C2776178081 @default.
- W2083840551 hasConcept C2776938444 @default.
- W2083840551 hasConcept C2776954882 @default.
- W2083840551 hasConcept C2777714996 @default.
- W2083840551 hasConcept C2778428886 @default.
- W2083840551 hasConcept C2778938600 @default.
- W2083840551 hasConcept C42219234 @default.
- W2083840551 hasConcept C71924100 @default.
- W2083840551 hasConcept C98274493 @default.
- W2083840551 hasConceptScore W2083840551C105922876 @default.
- W2083840551 hasConceptScore W2083840551C114682108 @default.
- W2083840551 hasConceptScore W2083840551C126322002 @default.
- W2083840551 hasConceptScore W2083840551C170493617 @default.
- W2083840551 hasConceptScore W2083840551C203014093 @default.
- W2083840551 hasConceptScore W2083840551C2776178081 @default.
- W2083840551 hasConceptScore W2083840551C2776938444 @default.
- W2083840551 hasConceptScore W2083840551C2776954882 @default.
- W2083840551 hasConceptScore W2083840551C2777714996 @default.
- W2083840551 hasConceptScore W2083840551C2778428886 @default.
- W2083840551 hasConceptScore W2083840551C2778938600 @default.
- W2083840551 hasConceptScore W2083840551C42219234 @default.
- W2083840551 hasConceptScore W2083840551C71924100 @default.
- W2083840551 hasConceptScore W2083840551C98274493 @default.
- W2083840551 hasIssue "11" @default.
- W2083840551 hasLocation W20838405511 @default.
- W2083840551 hasLocation W20838405512 @default.
- W2083840551 hasOpenAccess W2083840551 @default.
- W2083840551 hasPrimaryLocation W20838405511 @default.
- W2083840551 hasRelatedWork W1843063792 @default.
- W2083840551 hasRelatedWork W2007415402 @default.
- W2083840551 hasRelatedWork W2036200176 @default.
- W2083840551 hasRelatedWork W2066886381 @default.
- W2083840551 hasRelatedWork W2073663626 @default.
- W2083840551 hasRelatedWork W2116750280 @default.
- W2083840551 hasRelatedWork W2998100126 @default.
- W2083840551 hasRelatedWork W3138811744 @default.
- W2083840551 hasRelatedWork W4225416393 @default.
- W2083840551 hasRelatedWork W4306760109 @default.
- W2083840551 hasVolume "54" @default.
- W2083840551 isParatext "false" @default.
- W2083840551 isRetracted "false" @default.
- W2083840551 magId "2083840551" @default.
- W2083840551 workType "article" @default.