FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083843352> ?p ?o ?g. }

• W2083843352 endingPage "e1519" @default.
• W2083843352 startingPage "e1519" @default.
• W2083843352 abstract "Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent invasive fungal disease in South America. Systemic mycoses are the 10th most common cause of death among infectious diseases in Brazil and PCM is responsible for more than 50% of deaths due to fungal infections. PCM is typically treated with sulfonamides, amphotericin B or azoles, although complete eradication of the fungus may not occur and relapsing disease is frequently reported. A 15-mer peptide from the major diagnostic antigen gp43, named P10, can induce a strong T-CD4+ helper-1 immune response in mice. The TEPITOPE algorithm and experimental data have confirmed that most HLA-DR molecules can present P10, which suggests that P10 is a candidate antigen for a PCM vaccine. In the current work, the therapeutic efficacy of plasmid immunization with P10 and/or IL-12 inserts was tested in murine models of PCM. When given prior to or after infection with P. brasiliensis virulent Pb 18 isolate, plasmid-vaccination with P10 and/or IL-12 inserts successfully reduced the fungal burden in lungs of infected mice. In fact, intramuscular administration of a combination of plasmids expressing P10 and IL-12 given weekly for one month, followed by single injections every month for 3 months restored normal lung architecture and eradicated the fungus in mice that were infected one month prior to treatment. The data indicate that immunization with these plasmids is a powerful procedure for prevention and treatment of experimental PCM, with the perspective of being also effective in human patients." @default.
• W2083843352 created "2016-06-24" @default.
• W2083843352 creator A5000674089 @default.
• W2083843352 creator A5001312410 @default.
• W2083843352 creator A5038054771 @default.
• W2083843352 creator A5046520620 @default.
• W2083843352 creator A5074953319 @default.
• W2083843352 creator A5084305662 @default.
• W2083843352 date "2012-02-28" @default.
• W2083843352 modified "2023-10-03" @default.
• W2083843352 title "Therapeutic DNA Vaccine Encoding Peptide P10 against Experimental Paracoccidioidomycosis" @default.
• W2083843352 cites W1891793511 @default.
• W2083843352 cites W1968743131 @default.
• W2083843352 cites W1984119012 @default.
• W2083843352 cites W1992349622 @default.
• W2083843352 cites W1999225095 @default.
• W2083843352 cites W2006951240 @default.
• W2083843352 cites W2010788833 @default.
• W2083843352 cites W2010983951 @default.
• W2083843352 cites W2026554409 @default.
• W2083843352 cites W2031177528 @default.
• W2083843352 cites W2046862769 @default.
• W2083843352 cites W2051255331 @default.
• W2083843352 cites W2059063969 @default.
• W2083843352 cites W2069647916 @default.
• W2083843352 cites W2074025721 @default.
• W2083843352 cites W2088075996 @default.
• W2083843352 cites W2089868234 @default.
• W2083843352 cites W2094788013 @default.
• W2083843352 cites W2107367667 @default.
• W2083843352 cites W2108041709 @default.
• W2083843352 cites W2113051476 @default.
• W2083843352 cites W2118740247 @default.
• W2083843352 cites W2130125263 @default.
• W2083843352 cites W2136101546 @default.
• W2083843352 cites W2140882673 @default.
• W2083843352 cites W2143562420 @default.
• W2083843352 cites W2158681333 @default.
• W2083843352 cites W2164053600 @default.
• W2083843352 cites W2244240891 @default.
• W2083843352 doi "https://doi.org/10.1371/journal.pntd.0001519" @default.
• W2083843352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3289603" @default.
• W2083843352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22389734" @default.
• W2083843352 hasPublicationYear "2012" @default.
• W2083843352 type Work @default.
• W2083843352 sameAs 2083843352 @default.
• W2083843352 citedByCount "41" @default.
• W2083843352 countsByYear W20838433522012 @default.
• W2083843352 countsByYear W20838433522013 @default.
• W2083843352 countsByYear W20838433522014 @default.
• W2083843352 countsByYear W20838433522015 @default.
• W2083843352 countsByYear W20838433522016 @default.
• W2083843352 countsByYear W20838433522017 @default.
• W2083843352 countsByYear W20838433522019 @default.
• W2083843352 countsByYear W20838433522020 @default.
• W2083843352 countsByYear W20838433522021 @default.
• W2083843352 countsByYear W20838433522023 @default.
• W2083843352 crossrefType "journal-article" @default.
• W2083843352 hasAuthorship W2083843352A5000674089 @default.
• W2083843352 hasAuthorship W2083843352A5001312410 @default.
• W2083843352 hasAuthorship W2083843352A5038054771 @default.
• W2083843352 hasAuthorship W2083843352A5046520620 @default.
• W2083843352 hasAuthorship W2083843352A5074953319 @default.
• W2083843352 hasAuthorship W2083843352A5084305662 @default.
• W2083843352 hasBestOaLocation W20838433521 @default.
• W2083843352 hasConcept C104317684 @default.
• W2083843352 hasConcept C147483822 @default.
• W2083843352 hasConcept C159047783 @default.
• W2083843352 hasConcept C167508917 @default.
• W2083843352 hasConcept C203014093 @default.
• W2083843352 hasConcept C22070199 @default.
• W2083843352 hasConcept C22744801 @default.
• W2083843352 hasConcept C2777681368 @default.
• W2083843352 hasConcept C2779108831 @default.
• W2083843352 hasConcept C2780801004 @default.
• W2083843352 hasConcept C2909986799 @default.
• W2083843352 hasConcept C55493867 @default.
• W2083843352 hasConcept C60987743 @default.
• W2083843352 hasConcept C86803240 @default.
• W2083843352 hasConcept C8891405 @default.
• W2083843352 hasConcept C89423630 @default.
• W2083843352 hasConceptScore W2083843352C104317684 @default.
• W2083843352 hasConceptScore W2083843352C147483822 @default.
• W2083843352 hasConceptScore W2083843352C159047783 @default.
• W2083843352 hasConceptScore W2083843352C167508917 @default.
• W2083843352 hasConceptScore W2083843352C203014093 @default.
• W2083843352 hasConceptScore W2083843352C22070199 @default.
• W2083843352 hasConceptScore W2083843352C22744801 @default.
• W2083843352 hasConceptScore W2083843352C2777681368 @default.
• W2083843352 hasConceptScore W2083843352C2779108831 @default.
• W2083843352 hasConceptScore W2083843352C2780801004 @default.
• W2083843352 hasConceptScore W2083843352C2909986799 @default.
• W2083843352 hasConceptScore W2083843352C55493867 @default.
• W2083843352 hasConceptScore W2083843352C60987743 @default.
• W2083843352 hasConceptScore W2083843352C86803240 @default.
• W2083843352 hasConceptScore W2083843352C8891405 @default.
• W2083843352 hasConceptScore W2083843352C89423630 @default.
• W2083843352 hasIssue "2" @default.

• next