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- W2083845004 abstract "The correlation between the antispermatogenic activity of 1-[(4-chlorophenyl)methyl]-1H-indazole-3-car☐ylic acid (AF 1312/TS) and its serum and testicular concentrations was studied in rats. The doses used were between 100 and 500 mg/kg po or 125, 250 and 500 mg/kg po when the drug was given in a medicated diet. Duration of treatment was between 1 and 30 days. The minimal effective dose following a single administration was 300 mg/kg, corresponding to a peak serum concentration higher than 300 μg/ml, while the minimal effective dose for five daily administrations was 100 mg/kg, corresponding to a peak serum concentration lower than 200 μg/ml. When the drug was incorporated in the diet, the effective dose was 250 mg/kg daily, corresponding to serum concentrations of about 100 μg/ml. The efficacy of the drug was not increased when the duration of treatment was prolonged from 5 to 30 days. The critical testicular concentration for antispermatogenic activity was found to be about 10 μg/g." @default.
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- W2083845004 date "1977-10-01" @default.
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- W2083845004 title "Study of rat serum concentrations of 1-[(4-chlorophenyl)methyl]-1H-indazole-3-car☐ylic acid, new antispermatogenic agent" @default.
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- W2083845004 doi "https://doi.org/10.1016/0041-008x(77)90192-2" @default.
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