Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083856576> ?p ?o ?g. }
- W2083856576 endingPage "308" @default.
- W2083856576 startingPage "298" @default.
- W2083856576 abstract "The response to exposure of all-trans-retinoic acid (RA) during development varies from physiologic to severe teratogenic outcomes and is dependent upon the dose and the stage of development in all species. Effects of RA-mediated teratogenesis may be due to its ability to cause apoptosis. We have recently reported the modulation of p53 in murine stem cells by RA. The aim of this study was to characterize the temporal and spatial pattern of p53 expression in Swiss Webster mouse fetuses following maternal treatment with a single oral dose of 100 mg/kg body weight of RA during organogenesis. RA treatment resulted in a decreased p53 mRNA level in fetuses 24, 48, and 72 h after maternal treatment as detected by semiquantitative reverse transcriptase polymerase chain reaction. Western blot analysis showed a decrease in p53 protein at 24 and 48 h. Immunohistochemistry revealed decreased localization of p53 in the neuroepithelium of fetuses exposed to RA in utero. RA treatment also resulted in decreased nuclear p21 and decreased expression of cytosolic as well as nuclear p27 at 72 h in the fetuses. These results demonstrated that RA-mediated teratogenesis is accompanied by a reduction in the temporal and spatial pattern of p53 gene and protein expression in addition to the disruption of the cell cycle by modulation of p21 and p27." @default.
- W2083856576 created "2016-06-24" @default.
- W2083856576 creator A5001090733 @default.
- W2083856576 creator A5032143500 @default.
- W2083856576 date "2003-06-01" @default.
- W2083856576 modified "2023-09-24" @default.
- W2083856576 title "Modulation of p53 after maternal exposure to all-trans-retinoic acid in Swiss Webster mouse fetuses" @default.
- W2083856576 cites W131676287 @default.
- W2083856576 cites W1881393103 @default.
- W2083856576 cites W1970661735 @default.
- W2083856576 cites W1984094287 @default.
- W2083856576 cites W1990789332 @default.
- W2083856576 cites W2003185547 @default.
- W2083856576 cites W2015519364 @default.
- W2083856576 cites W2024349738 @default.
- W2083856576 cites W2025735471 @default.
- W2083856576 cites W2027736032 @default.
- W2083856576 cites W2041758079 @default.
- W2083856576 cites W2045872949 @default.
- W2083856576 cites W2049577262 @default.
- W2083856576 cites W2056079046 @default.
- W2083856576 cites W2058960071 @default.
- W2083856576 cites W2065886732 @default.
- W2083856576 cites W2068791781 @default.
- W2083856576 cites W2070061120 @default.
- W2083856576 cites W2072088194 @default.
- W2083856576 cites W2072809813 @default.
- W2083856576 cites W2074786828 @default.
- W2083856576 cites W2081290278 @default.
- W2083856576 cites W2083803749 @default.
- W2083856576 cites W2084957844 @default.
- W2083856576 cites W2089218510 @default.
- W2083856576 cites W2094859123 @default.
- W2083856576 cites W2124139409 @default.
- W2083856576 cites W2126679757 @default.
- W2083856576 cites W2137825815 @default.
- W2083856576 cites W2147242002 @default.
- W2083856576 cites W2150710841 @default.
- W2083856576 cites W2152511054 @default.
- W2083856576 cites W2154381385 @default.
- W2083856576 cites W2159199900 @default.
- W2083856576 cites W2160698217 @default.
- W2083856576 cites W2167717341 @default.
- W2083856576 cites W2337949001 @default.
- W2083856576 cites W2356484699 @default.
- W2083856576 cites W2079096705 @default.
- W2083856576 doi "https://doi.org/10.1016/s0014-4800(02)00018-7" @default.
- W2083856576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12782018" @default.
- W2083856576 hasPublicationYear "2003" @default.
- W2083856576 type Work @default.
- W2083856576 sameAs 2083856576 @default.
- W2083856576 citedByCount "3" @default.
- W2083856576 crossrefType "journal-article" @default.
- W2083856576 hasAuthorship W2083856576A5001090733 @default.
- W2083856576 hasAuthorship W2083856576A5032143500 @default.
- W2083856576 hasConcept C104317684 @default.
- W2083856576 hasConcept C126322002 @default.
- W2083856576 hasConcept C134018914 @default.
- W2083856576 hasConcept C150194340 @default.
- W2083856576 hasConcept C16685009 @default.
- W2083856576 hasConcept C172680121 @default.
- W2083856576 hasConcept C201614185 @default.
- W2083856576 hasConcept C203014093 @default.
- W2083856576 hasConcept C204232928 @default.
- W2083856576 hasConcept C2776415932 @default.
- W2083856576 hasConcept C2779234561 @default.
- W2083856576 hasConcept C2781121885 @default.
- W2083856576 hasConcept C54355233 @default.
- W2083856576 hasConcept C55493867 @default.
- W2083856576 hasConcept C71924100 @default.
- W2083856576 hasConcept C81439078 @default.
- W2083856576 hasConcept C81885089 @default.
- W2083856576 hasConcept C85265743 @default.
- W2083856576 hasConcept C86803240 @default.
- W2083856576 hasConceptScore W2083856576C104317684 @default.
- W2083856576 hasConceptScore W2083856576C126322002 @default.
- W2083856576 hasConceptScore W2083856576C134018914 @default.
- W2083856576 hasConceptScore W2083856576C150194340 @default.
- W2083856576 hasConceptScore W2083856576C16685009 @default.
- W2083856576 hasConceptScore W2083856576C172680121 @default.
- W2083856576 hasConceptScore W2083856576C201614185 @default.
- W2083856576 hasConceptScore W2083856576C203014093 @default.
- W2083856576 hasConceptScore W2083856576C204232928 @default.
- W2083856576 hasConceptScore W2083856576C2776415932 @default.
- W2083856576 hasConceptScore W2083856576C2779234561 @default.
- W2083856576 hasConceptScore W2083856576C2781121885 @default.
- W2083856576 hasConceptScore W2083856576C54355233 @default.
- W2083856576 hasConceptScore W2083856576C55493867 @default.
- W2083856576 hasConceptScore W2083856576C71924100 @default.
- W2083856576 hasConceptScore W2083856576C81439078 @default.
- W2083856576 hasConceptScore W2083856576C81885089 @default.
- W2083856576 hasConceptScore W2083856576C85265743 @default.
- W2083856576 hasConceptScore W2083856576C86803240 @default.
- W2083856576 hasIssue "3" @default.
- W2083856576 hasLocation W20838565761 @default.
- W2083856576 hasLocation W20838565762 @default.
- W2083856576 hasOpenAccess W2083856576 @default.
- W2083856576 hasPrimaryLocation W20838565761 @default.