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• W2083876008 abstract "<i>Background/Aim:</i> Vascular endothelial growth factor (VEGF), required for renal development, is generated by alternative splicing of 8 exons to produce two families, pro-angiogenic VEGF_xxx, formed by proximal splicing in exon 8 (exon 8a), and anti-angiogenic VEGF_xxxb, generated by distal splicing in exon 8 (exon 8b). VEGF₁₆₅b, the first described exon 8b-containing isoform, antagonises VEGF₁₆₅ and is anti-angiogenic in vivo. <i>Methods:</i> Using VEGF_xxxb-specific antibodies, we investigated its expression quantitatively and qualitatively in developing kidney, and measured the effect of VEGF₁₆₅b on renal endothelial and epithelial cells. <i>Results:</i> VEGF_xxxb formed 45% of total VEGF protein in adult renal cortex, and VEGF₁₆₅b does not increase glomerular endothelial cell permeability, it inhibits migration, and is cytoprotective for podocytes. During renal development, VEGF_xxxb was expressed in the condensed vesicles of the metanephros, epithelial cells of the comma-shaped bodies, invading endothelial cells and epithelial cells of the S-shaped body, and in the immature podocytes. Expression reduced as the glomerulus matured. <i>Conclusion:</i> These results show that the anti-angiogenic VEGF_xxxb isoforms are highly expressed in adult and developing renal cortex, and suggest that the VEGF_xxxb family plays a role in glomerular maturation and podocyte protection by regulating the pro-angiogenic pro-permeability properties of VEGF_xxx isoforms." @default.
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• W2083876008 date "2008-11-27" @default.
• W2083876008 modified "2023-10-17" @default.
• W2083876008 title "The Alternatively Spliced Anti-Angiogenic Family of VEGF Isoforms VEGF_xxxb in Human Kidney Development" @default.
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• W2083876008 doi "https://doi.org/10.1159/000177614" @default.
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