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- W2083878051 abstract "14C-prazepam (7-chloro-1-cyclopropylmethyl-5-phenyl-1H-1,4-benzodiazepin-2-one) labeled either in the 5-phenyl ring or in the cyclo propyl sidechain, was incubated with 9000 g supernatant fractions prepared from livers of dogs, untreated and phenobarbital-treated rats, and untreated and phenobarbital-treated mice. Ring-labeled prazepam was also incubated with liver supernatants from humans. N-dealkylation was the major pathway of prazepam metabolism in vitro. The liver enzymes of all species except untreated mice were able to metabolize prazepam to varying amounts of oxazepam. Pretreatment of rats and mice with phenobarbital resulted in an increase of both desalklprazepam and oxazepam formation from prazepam." @default.
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- W2083878051 date "1972-02-01" @default.
- W2083878051 modified "2023-09-25" @default.
- W2083878051 title "Prazepam metabolism in vitro" @default.
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- W2083878051 doi "https://doi.org/10.1016/0006-2952(72)90331-0" @default.
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