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- W2083929213 abstract "Clearance of recruited immune cells is necessary to resolve inflammatory reactions. We show here that matrix metalloproteinase 2 (MMP2), as part of an interleukin 13 (IL-13)–dependent regulatory loop, dampens inflammation by promoting the egress of inflammatory cells into the airway lumen. MMP2−/− mice showed a robust asthma phenotype and increased susceptibility to asphyxiation induced by allergens. However, whereas the lack of MMP2 reduced the influx of cells into bronchoalveolar lavage (BAL), numerous inflammatory cells accumulated in the lung parenchyma. BAL of MMP2−/− mice lacked normal chemotactic activity, whereas lung inflammatory cells from the same mice showed appropriate chemotactic responses. Thus, MMP2 establishes the chemotactic gradient required for egression of lung inflammatory cells and prevention of lethal asphyxiation." @default.
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- W2083929213 date "2002-03-11" @default.
- W2083929213 modified "2023-09-22" @default.
- W2083929213 title "Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency" @default.
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- W2083929213 doi "https://doi.org/10.1038/ni773" @default.
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