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- W2083929748 abstract "It is well known that malignant cells circulate in the bloodstream of patients with solid tumors. However, the biological significance of circulating tumor cells (CTCs) and the clinical relevance of their detection are still debated. Besides technical issues regarding CTC-detection methods, discontinuous shedding of CTCs from established cancer deposits, genomic instability and metastatic inefficiency might underlie the conflicting results currently available. Nevertheless, technological advances and recent clinical findings are prompting researchers to dissect CTC biology further. Here, we review these recent findings, and discuss the prospects for the identification and molecular characterization of the CTC subset that is responsible for metastasis development. This would provide a formidable tool for prognosis evaluation, anticancer-drug development and, ultimately, cancer-therapy personalization. It is well known that malignant cells circulate in the bloodstream of patients with solid tumors. However, the biological significance of circulating tumor cells (CTCs) and the clinical relevance of their detection are still debated. Besides technical issues regarding CTC-detection methods, discontinuous shedding of CTCs from established cancer deposits, genomic instability and metastatic inefficiency might underlie the conflicting results currently available. Nevertheless, technological advances and recent clinical findings are prompting researchers to dissect CTC biology further. Here, we review these recent findings, and discuss the prospects for the identification and molecular characterization of the CTC subset that is responsible for metastasis development. This would provide a formidable tool for prognosis evaluation, anticancer-drug development and, ultimately, cancer-therapy personalization. the statistical error (also known as type-II error) made in testing an hypothesis when it is concluded that an intervention (or prediction) is not effective (or true) but it really is. any biotechnology aimed at sorting target cells (e.g. CTCs) from a pool of ‘unwanted’ cells (e.g. peripheral mononucleated cells) to increase the number of cells of interest per unit of volume (enrichment) and thus enable collection of enough biological material for molecular analysis. the pathological tendency of the genome of some cells (typically malignant cells) to undergo molecular alterations (e.g. gene mutations or deletions and chromosomal translocation or deletions). Genomic instability has a key role in cancer development and progression. the low-level presence of any transcripts in any cell. Accordingly, using PCR, illegitimate mRNA of any gene can be potentially amplified from any tissue or cell type. the phenomenon by which only a subset of malignant cells can metastasize because of its metastatic molecular profile. the microscopic tumor remnants that can persist after apparently radical treatments and that can cause disease recurrence. It is detectable only with cytometric or molecular methods (but not with currently available radiology imaging). a sequence of DNA that is similar to a normal gene but that has been altered slightly so it is not expressed. Such genes were probably once functional but, during evolution, have acquired one or more mutations that rendered them unable to produce a protein product. tumor-type-specific staging system that takes into consideration tumor size (T), lymph-node involvement (N) and presence or absence of distant metastasis (M)." @default.
- W2083929748 created "2016-06-24" @default.
- W2083929748 creator A5008759910 @default.
- W2083929748 creator A5009562018 @default.
- W2083929748 creator A5010324991 @default.
- W2083929748 creator A5066640097 @default.
- W2083929748 date "2006-03-01" @default.
- W2083929748 modified "2023-10-14" @default.
- W2083929748 title "Circulating tumor cells: the ‘leukemic phase’ of solid cancers" @default.
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- W2083929748 doi "https://doi.org/10.1016/j.molmed.2006.01.006" @default.
- W2083929748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16488189" @default.
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