Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083934724> ?p ?o ?g. }
- W2083934724 endingPage "1578" @default.
- W2083934724 startingPage "1573" @default.
- W2083934724 abstract "Based on the Entamoeba histolytica genome project ( www.sanger.ac.uk/Projects/E_histolytica/ ) we have identified a cysteine protease inhibitor, EhICP1 (amoebiasin 1), with significant homology to chagasin. Recombinant EhICP1 inhibited the protease activity of papain and that of a trophozoite lysate with K i 's in the picomolar range. By immunocytology, we localized the endogenous ∼13 kDa EhICP1 in a finely dotted subcellular distribution discrete from the vesicles containing the amoebic cysteine protease, EhCP1 (amoebapain). In an overlay assay, we observed binding of recombinant EhICP1 to EhCP1. As a heptapeptide (GNPTTGF) corresponding to the second conserved chagasin motif inhibited the protease activity of both papain ( K i 1.5 μM) and trophozoite extract ( K i in sub‐mM range), it may be a candidate for the rational development of anti‐amoebiasis drugs." @default.
- W2083934724 created "2016-06-24" @default.
- W2083934724 creator A5012664650 @default.
- W2083934724 creator A5047320258 @default.
- W2083934724 creator A5052233108 @default.
- W2083934724 creator A5064759702 @default.
- W2083934724 creator A5072964616 @default.
- W2083934724 date "2005-02-12" @default.
- W2083934724 modified "2023-10-13" @default.
- W2083934724 title "Identification of EhICP1, a chagasin-like cysteine protease inhibitor of<i>Entamoeba histolytica</i>" @default.
- W2083934724 cites W1192485014 @default.
- W2083934724 cites W1492192545 @default.
- W2083934724 cites W1541720947 @default.
- W2083934724 cites W1732196838 @default.
- W2083934724 cites W1932052686 @default.
- W2083934724 cites W1950275427 @default.
- W2083934724 cites W2013470743 @default.
- W2083934724 cites W2042497267 @default.
- W2083934724 cites W2048436287 @default.
- W2083934724 cites W2057931763 @default.
- W2083934724 cites W2060266279 @default.
- W2083934724 cites W2077752559 @default.
- W2083934724 cites W2098218336 @default.
- W2083934724 cites W2102792735 @default.
- W2083934724 cites W2129344220 @default.
- W2083934724 cites W2132670203 @default.
- W2083934724 cites W2132916493 @default.
- W2083934724 cites W2141426625 @default.
- W2083934724 cites W2143302258 @default.
- W2083934724 cites W2144439563 @default.
- W2083934724 cites W2158783623 @default.
- W2083934724 cites W2160575327 @default.
- W2083934724 cites W2168723094 @default.
- W2083934724 cites W2414435754 @default.
- W2083934724 cites W3027294608 @default.
- W2083934724 cites W942049167 @default.
- W2083934724 doi "https://doi.org/10.1016/j.febslet.2005.01.067" @default.
- W2083934724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15757643" @default.
- W2083934724 hasPublicationYear "2005" @default.
- W2083934724 type Work @default.
- W2083934724 sameAs 2083934724 @default.
- W2083934724 citedByCount "42" @default.
- W2083934724 countsByYear W20839347242012 @default.
- W2083934724 countsByYear W20839347242013 @default.
- W2083934724 countsByYear W20839347242014 @default.
- W2083934724 countsByYear W20839347242015 @default.
- W2083934724 countsByYear W20839347242016 @default.
- W2083934724 countsByYear W20839347242019 @default.
- W2083934724 countsByYear W20839347242020 @default.
- W2083934724 countsByYear W20839347242021 @default.
- W2083934724 countsByYear W20839347242022 @default.
- W2083934724 countsByYear W20839347242023 @default.
- W2083934724 crossrefType "journal-article" @default.
- W2083934724 hasAuthorship W2083934724A5012664650 @default.
- W2083934724 hasAuthorship W2083934724A5047320258 @default.
- W2083934724 hasAuthorship W2083934724A5052233108 @default.
- W2083934724 hasAuthorship W2083934724A5064759702 @default.
- W2083934724 hasAuthorship W2083934724A5072964616 @default.
- W2083934724 hasBestOaLocation W20839347241 @default.
- W2083934724 hasConcept C104317684 @default.
- W2083934724 hasConcept C142462285 @default.
- W2083934724 hasConcept C153911025 @default.
- W2083934724 hasConcept C159047783 @default.
- W2083934724 hasConcept C159641895 @default.
- W2083934724 hasConcept C181199279 @default.
- W2083934724 hasConcept C182220744 @default.
- W2083934724 hasConcept C185592680 @default.
- W2083934724 hasConcept C190283241 @default.
- W2083934724 hasConcept C2776714187 @default.
- W2083934724 hasConcept C2776867272 @default.
- W2083934724 hasConcept C2777283782 @default.
- W2083934724 hasConcept C2777473665 @default.
- W2083934724 hasConcept C2779201268 @default.
- W2083934724 hasConcept C2779548226 @default.
- W2083934724 hasConcept C2779832904 @default.
- W2083934724 hasConcept C2780412452 @default.
- W2083934724 hasConcept C2781143361 @default.
- W2083934724 hasConcept C2908725733 @default.
- W2083934724 hasConcept C2993143319 @default.
- W2083934724 hasConcept C3013748606 @default.
- W2083934724 hasConcept C31573885 @default.
- W2083934724 hasConcept C40767141 @default.
- W2083934724 hasConcept C55493867 @default.
- W2083934724 hasConcept C86803240 @default.
- W2083934724 hasConcept C89423630 @default.
- W2083934724 hasConcept C98424977 @default.
- W2083934724 hasConceptScore W2083934724C104317684 @default.
- W2083934724 hasConceptScore W2083934724C142462285 @default.
- W2083934724 hasConceptScore W2083934724C153911025 @default.
- W2083934724 hasConceptScore W2083934724C159047783 @default.
- W2083934724 hasConceptScore W2083934724C159641895 @default.
- W2083934724 hasConceptScore W2083934724C181199279 @default.
- W2083934724 hasConceptScore W2083934724C182220744 @default.
- W2083934724 hasConceptScore W2083934724C185592680 @default.
- W2083934724 hasConceptScore W2083934724C190283241 @default.
- W2083934724 hasConceptScore W2083934724C2776714187 @default.
- W2083934724 hasConceptScore W2083934724C2776867272 @default.
- W2083934724 hasConceptScore W2083934724C2777283782 @default.