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- W2083942008 abstract "In a bioassay-guided search for antimycobacterial compounds from higher plants, we have chemically investigated methanolic extracts of seeds of Melia volkensii. Chromatographic fractions provided two new euphane (20R)-type triterpenoids. The structures of the new compounds, 12β-hydroxykulactone (1) and 6β-hydroxykulactone (2), were elucidated by 1D and 2D NMR (13C, 1H, 1H−1H COSY, HMQC, HMBC, and NOESY spectra) and FABMS studies and shown to be hydroxyl derivatives of kulactone (3). Also isolated was the known kulonate (4). In a radiorespirometric bioassay against Mycobacterium tuberculosis, compounds 1, 2, and 4 exhibited minimum inhibitory concentrations of 16, 4, and 16 μg/mL, respectively." @default.
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- W2083942008 date "1999-03-12" @default.
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- W2083942008 title "Antimycobacterial Triterpenes from <i>Melia </i><i>v</i><i>olkensii</i>" @default.
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- W2083942008 doi "https://doi.org/10.1021/np980288u" @default.
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