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- W2083966730 abstract "Background: The aim of this study is to evaluate the gene expression of immune‐inflammatory markers in gingival biopsies of patients with type 2 diabetes with chronic periodontitis (CP). Methods: Gingival biopsies were harvested from systemically and periodontally healthy patients (SPH), systemically healthy patients with CP (SHCP), and patients with better‐controlled and poorly controlled diabetes and CP. The levels of mRNA of interleukin (IL)‐17, IL‐6, IL‐23, IL‐10, IL‐4, interferon‐γ, toll‐like receptor (TLR)‐2, TLR‐4, osteoprotegerin, receptor activator of nuclear factor‐kappa B ligand (RANKL), tumor necrosis factor‐α, transforming growth factor‐β, transcription factor forkhead box p3, transcription factor orphan nuclear receptor C2 (RORC2), and receptor of advanced glycation end products (RAGE) were evaluated by quantitative real‐time polymerase chain reaction. Results: All CP groups presented higher levels of mRNA of TLR‐2, TLR‐4, IL‐17, RANKL, and RAGE and a higher frequency of IL‐17 and TLR‐2 mRNA‐positive biopsies when compared to SPH ( P <0.05). There was a higher frequency of detection of RORC2 in the biopsies from both groups with diabetes compared to the other groups ( P <0.05). The frequency of IL‐4 mRNA‐positive tissues was lower in patients with diabetes compared to SHCP ( P <0.05). Conclusion: CP, but not type 2 diabetes mellitus, significantly affected the expressions of the evaluated genes related to the innate and adaptive immune responses." @default.
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- W2083966730 date "2012-04-01" @default.
- W2083966730 modified "2023-09-30" @default.
- W2083966730 title "Expression of Immune-Inflammatory Markers in Sites of Chronic Periodontitis in Patients With Type 2 Diabetes" @default.
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- W2083966730 doi "https://doi.org/10.1902/jop.2011.110324" @default.
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