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• W2083968123 abstract "Type 1 diabetes (T1D) is an autoimmune disease characterised by immunity to pancreatic beta-cell autoantigens, associated with beta-cell destruction leading to insulin deficiency and hyperglycaemia. The rigorous definition of an autoimmune disease requires evidence that an autoantigen elicits pathological immune responses. Using criteria for the pathogenicity of an autoantigen, we examine the evidence for proinsulin as an autoantigen in T1D. We conclude that proinsulin satisfies these criteria. As a corollary, proinsulin is a potential immunotherapeutic tool for the prevention of T1D." @default.
• W2083968123 created "2016-06-24" @default.
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• W2083968123 date "2003-06-01" @default.
• W2083968123 modified "2023-10-18" @default.
• W2083968123 title "Proinsulin—a pathogenic autoantigen in type 1 diabetes" @default.
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• W2083968123 doi "https://doi.org/10.1016/s1568-9972(03)00009-0" @default.
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