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• W2083976314 abstract "Kindling is a permanent form of brain change that results from repeated elicitation of epileptiform neural activity, c-fos has been proposed as the gene responsible for turning on molecular events that might underlie the long-term changes that occur during kindling. This study investigated the enhancement of c-fos levels following kindled seizures and the role of c-fos in the plastic changes underlying kindling. Male hooded rats were electrically kindled in the amygdala and the resulting c-fos and c-Ha-ras gene expression was quantified using Northern blot hybridization analysis. The results indicated that c-fos was constitutively expressed in forebrain and cerebellum, and that basal levels of c-fos were equivalent in naive and in fully kindled rats that have been seizure-free for 3 weeks. Following an amygdala-piriform kindled seizure there was a massive and transient increase in c-fos levels throughout forebrain and cerebellum. Although enhanced c-fos levels were correlated with afterdischarge (AD) duration in the kindled site, enhanced c-fos levels were also observed in the amygdala-piriform contralateral to the kindled site, and the enhancement did not depend on the occurrence of AD in the contralateral amygdala-piriform. Furthermore, electrical stimulations not resulting in AD as well as other forms of control stimulation also increased c-fos levels. We conclude that c-fos was expressed simply as a consequence of neural activity and not exclusively due to the specific neural activity or underlying plastic change required for kindling. This does not preclude a role for c-fos in the long-term response to external stimuli, but it does suggest that c-fos is not the crucial ‘master switch’ in turning on a molecular program that might underlie kindling." @default.
• W2083976314 created "2016-06-24" @default.
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• W2083976314 date "1991-08-01" @default.
• W2083976314 modified "2023-09-26" @default.
• W2083976314 title "Expression of the proto-oncogene c-fos following electrical kindling in the rat" @default.
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• W2083976314 doi "https://doi.org/10.1016/0169-328x(91)90014-o" @default.
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