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- W2083977403 abstract "Noradrenaline can modulate multiple cellular functions important for cancer progression; however, how this single extracellular signal regulates such a broad array of cellular processes is unknown. Here we identify Src as a key regulator of phosphoproteomic signalling networks activated in response to beta-adrenergic signalling in cancer cells. These results also identify a new mechanism of Src phosphorylation that mediates beta-adrenergic/PKA regulation of downstream networks, thereby enhancing tumour cell migration, invasion and growth. In human ovarian cancer samples, high tumoural noradrenaline levels were correlated with high pSrcY419 levels. Moreover, among cancer patients, the use of beta blockers was significantly associated with reduced cancer-related mortality. Collectively, these data provide a pivotal molecular target for disrupting neural signalling in the tumour microenvironment. The neurotransmitter noradrenaline can regulate cellular processes that contribute to cancer progression, but the underlying mechanisms remain largely unknown. Here the authors identify Src as a key mediator of noradrenaline signalling networks in tumour metastasis." @default.
- W2083977403 created "2016-06-24" @default.
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- W2083977403 date "2013-01-29" @default.
- W2083977403 modified "2023-10-18" @default.
- W2083977403 title "Src activation by β-adrenoreceptors is a key switch for tumour metastasis" @default.
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- W2083977403 doi "https://doi.org/10.1038/ncomms2413" @default.
- W2083977403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561638" @default.
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- W2083977403 hasPublicationYear "2013" @default.
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