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• W2083979782 abstract "In an effort to identify promising non-hydroxamate inhibitors of matrix metalloproteinases (MMPs) several new zinc-binding groups (ZBGs) based on pyridine-derived or aza-macrocycle chelators have been examined. Fluorescence-based enzyme assays have been used to determine the IC50 values for these ZBGs against MMP-1, MMP-3, and anthrax lethal factor (LF). Many of these ligands were found to be remarkably potent, with IC50 values as much as 185-fold lower than that found for acetohydroxamic acid. These ligands are proposed to be more selective “warheads” for the inhibition of metalloenzymes that contain Zn2+ versus other metal ions at their active site." @default.
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• W2083979782 date "2006-02-21" @default.
• W2083979782 modified "2023-09-24" @default.
• W2083979782 title "A New Role for Old Ligands: Discerning Chelators for Zinc Metalloproteinases" @default.
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• W2083979782 doi "https://doi.org/10.1021/ja057957s" @default.
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