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- W2083982114 endingPage "1038" @default.
- W2083982114 startingPage "1029" @default.
- W2083982114 abstract "1. N-Hydroxyamphetamine and N-hydroxymetharnphetamine, metabolic intermediates of amphetamine and methamphetamine, showed no reactivity towards endogeneous protein, amino acids, nucleic acids and fatty acids. In contrast, formaldehyde, acetaldehyde and propionaldehyde reacted well with N-hydroxyamphetamine and slightly with N-hydroxymethamphetamine under mild conditions (pH 7.4, 37°C).2. Two products were isolated from the reaction mixture of acetaldehyde and N-hydroxyamphetamine. These were characterized as N-[(1-methyl-2-phenyl)ethyl]ethani-mine N-oxide and N-[(1-methyl-2-phenyl)ethyl]butenimine N-oxide by mass and n.m.r. spectrometries.3. N-[(1-Methyl-2-phenyl)ethyl]ethanimine N-oxide was formed by incubating methamphetamine with liver 9000 g supernatants of rats and guinea-pigs. The butenimine N-oxide derivative, however, could not be detected as a metabolite of methamphetamine in vitro.4. N-[(1-Methyl-2-phenyl)ethyl]ethanimine N-oxide was also detected as a urinary metabolite of methamphetamine in rats and guinea-pigs. Thus, the ethanimine N-oxide was established as a novel metabolite of methamphetamine." @default.
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- W2083982114 date "1987-01-01" @default.
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- W2083982114 title "A new metabolite of methamphetamine; evidence for formation of<i>N</i>-[(1-methyl-2-phenyl)ethyl]ethanimine<i>N</i>-oxide" @default.
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- W2083982114 doi "https://doi.org/10.3109/00498258709044201" @default.
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