FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083992410> ?p ?o ?g. }

• W2083992410 endingPage "784" @default.
• W2083992410 startingPage "777" @default.
• W2083992410 abstract "The precise contribution of left atrial appendage (LAA) endocardial damage and dysfunction to the process of thrombus formation in patients with mitral valve (MV) disease, especially in the presence of atrial fibrillation (AF), has not as yet been clearly described. This may be important because the LAA is the usual site for thrombus formation.The purpose of this study was to describe endocardial surface changes, through the use of scanning electron microscopy, in the left and right atrial appendages of patients with MV disease and the differences, if any, between patients with mitral stenosis and mitral regurgitation as well as between those with AF and sinus rhythm. Our second objective was to relate endocardial changes to plasma levels of von Willebrand factor (vWf), an established marker for endothelial damage. LAA specimens were obtained immediately after commencement of cardiopulmonary bypass from 35 patients (18 men; mean age 65 years, range 20 to 85) during surgery for MV repair or replacement. Right atrial appendage (RAA) specimens were similarly obtained as controls for individual patients. The specimens were fixed in 2.5% glutaraldehyde solution overnight, stored in Sorensen's phosphate buffer, and examined by means of scanning electron microscopy. Two independent observers documented the most advanced lesion in each specimen as follows: (1) minimal changes, with minimal disruption of the endocardium; (2) intermediate changes or prethrombotic lesions; and (3) advanced changes, with endocardial disruption and thrombotic lesions. Plasma levels of vWf were also measured (enzyme-linked immunosorbent assay) in all patients, and results were compared with those of age- and sex-matched healthy control patients.Advanced changes were more frequently seen in the endocardium of the LAA when compared with the RAA (31% vs 6%), whereas minimal changes were more frequently seen in the RAA compared with the LAA (23% vs 6%) (P =.00167). Similarly, the LAA from patients with mitral stenosis had a higher proportion of advanced endocardial changes when compared with patients with mitral regurgitation (67% vs 24%; P =.0066). The LAA in patients with AF had more advanced changes (39% vs 27%), but this was not statistically significant. Plasma vWf levels were significantly higher in patients with MV disease compared with healthy control patients (132 +/- 33 IU/dL vs 99 +/- 37 IU/dL; P =.0004) and in patients with advanced LAA changes compared with earlier changes (149 +/- 34 IU/dL vs 121 +/- 31 IU/dL; P =.042).Endocardial damage occurs in the atrial appendages of patients with MV disease. Potentially thrombogenic changes are more commonly seen in the LAA compared with the RAA and in patients with mitral stenosis compared with mitral regurgitation. These anatomic appearances may contribute to the risk of intra-atrial thrombus formation in patients with mitral valve disease, especially if AF is present." @default.
• W2083992410 created "2016-06-24" @default.
• W2083992410 creator A5010926915 @default.
• W2083992410 creator A5050407708 @default.
• W2083992410 creator A5059092618 @default.
• W2083992410 creator A5066710703 @default.
• W2083992410 creator A5076002640 @default.
• W2083992410 creator A5091713074 @default.
• W2083992410 date "2000-11-01" @default.
• W2083992410 modified "2023-10-13" @default.
• W2083992410 title "Atrial endocardial changes in mitral valve disease: A scanning electron microscopy study" @default.
• W2083992410 cites W1986161881 @default.
• W2083992410 cites W1987536945 @default.
• W2083992410 cites W1992349148 @default.
• W2083992410 cites W2009251691 @default.
• W2083992410 cites W2018803964 @default.
• W2083992410 cites W2036054742 @default.
• W2083992410 cites W2036747400 @default.
• W2083992410 cites W2042591239 @default.
• W2083992410 cites W2056004266 @default.
• W2083992410 cites W2059161833 @default.
• W2083992410 cites W2069849931 @default.
• W2083992410 cites W2107781166 @default.
• W2083992410 cites W2125574010 @default.
• W2083992410 cites W2143159730 @default.
• W2083992410 cites W2156390580 @default.
• W2083992410 cites W2169381152 @default.
• W2083992410 cites W2175263209 @default.
• W2083992410 cites W2236425734 @default.
• W2083992410 cites W2021754791 @default.
• W2083992410 doi "https://doi.org/10.1067/mhj.2000.110284" @default.
• W2083992410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11054625" @default.
• W2083992410 hasPublicationYear "2000" @default.
• W2083992410 type Work @default.
• W2083992410 sameAs 2083992410 @default.
• W2083992410 citedByCount "96" @default.
• W2083992410 countsByYear W20839924102012 @default.
• W2083992410 countsByYear W20839924102013 @default.
• W2083992410 countsByYear W20839924102014 @default.
• W2083992410 countsByYear W20839924102015 @default.
• W2083992410 countsByYear W20839924102016 @default.
• W2083992410 countsByYear W20839924102017 @default.
• W2083992410 countsByYear W20839924102018 @default.
• W2083992410 countsByYear W20839924102019 @default.
• W2083992410 countsByYear W20839924102020 @default.
• W2083992410 countsByYear W20839924102021 @default.
• W2083992410 countsByYear W20839924102022 @default.
• W2083992410 countsByYear W20839924102023 @default.
• W2083992410 crossrefType "journal-article" @default.
• W2083992410 hasAuthorship W2083992410A5010926915 @default.
• W2083992410 hasAuthorship W2083992410A5050407708 @default.
• W2083992410 hasAuthorship W2083992410A5059092618 @default.
• W2083992410 hasAuthorship W2083992410A5066710703 @default.
• W2083992410 hasAuthorship W2083992410A5076002640 @default.
• W2083992410 hasAuthorship W2083992410A5091713074 @default.
• W2083992410 hasConcept C126322002 @default.
• W2083992410 hasConcept C164705383 @default.
• W2083992410 hasConcept C2775914520 @default.
• W2083992410 hasConcept C2777543888 @default.
• W2083992410 hasConcept C2779161974 @default.
• W2083992410 hasConcept C2779394231 @default.
• W2083992410 hasConcept C2780007028 @default.
• W2083992410 hasConcept C2780074459 @default.
• W2083992410 hasConcept C2780703314 @default.
• W2083992410 hasConcept C2781362458 @default.
• W2083992410 hasConcept C2910272107 @default.
• W2083992410 hasConcept C2993373945 @default.
• W2083992410 hasConcept C71924100 @default.
• W2083992410 hasConcept C85378888 @default.
• W2083992410 hasConcept C89560881 @default.
• W2083992410 hasConceptScore W2083992410C126322002 @default.
• W2083992410 hasConceptScore W2083992410C164705383 @default.
• W2083992410 hasConceptScore W2083992410C2775914520 @default.
• W2083992410 hasConceptScore W2083992410C2777543888 @default.
• W2083992410 hasConceptScore W2083992410C2779161974 @default.
• W2083992410 hasConceptScore W2083992410C2779394231 @default.
• W2083992410 hasConceptScore W2083992410C2780007028 @default.
• W2083992410 hasConceptScore W2083992410C2780074459 @default.
• W2083992410 hasConceptScore W2083992410C2780703314 @default.
• W2083992410 hasConceptScore W2083992410C2781362458 @default.
• W2083992410 hasConceptScore W2083992410C2910272107 @default.
• W2083992410 hasConceptScore W2083992410C2993373945 @default.
• W2083992410 hasConceptScore W2083992410C71924100 @default.
• W2083992410 hasConceptScore W2083992410C85378888 @default.
• W2083992410 hasConceptScore W2083992410C89560881 @default.
• W2083992410 hasIssue "5" @default.
• W2083992410 hasLocation W20839924101 @default.
• W2083992410 hasLocation W20839924102 @default.
• W2083992410 hasOpenAccess W2083992410 @default.
• W2083992410 hasPrimaryLocation W20839924101 @default.
• W2083992410 hasRelatedWork W2030181133 @default.
• W2083992410 hasRelatedWork W2052497555 @default.
• W2083992410 hasRelatedWork W2097787009 @default.
• W2083992410 hasRelatedWork W2123323608 @default.
• W2083992410 hasRelatedWork W2167466854 @default.
• W2083992410 hasRelatedWork W2407982881 @default.
• W2083992410 hasRelatedWork W2920640915 @default.
• W2083992410 hasRelatedWork W2937909273 @default.

• next