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• W2083992760 abstract "A high proportion of oncogenes and tumor suppressor genes encode transcription factors. Deregulated expression or activation and inactivation of transcription factors as well as mutations and translocations play critical roles in tumorigenesis. Furthermore, the majority of oncogenic signaling pathways converge on sets of transcription factors that ultimately control gene expression patterns resulting in tumor formation and progression as well as metastasis. Under normal physiological conditions whole sets of genes with similar functions are regulated by highly specific, tightly regulated upstream transcriptional regulators, whereas in cancer aberrant activation of these transcription factors leads to deregulated expression of multiple gene sets associated with tumor development and progression. The activity of these transcription factors can be modulated by multiple mechanisms including posttranslational modifications. Activation or inactivation of transcription factors promote cancer development, cell survival and proliferation and induce tumor angiogenesis. Since many of these transcription factors are inactive under normal physiological conditions and their expression and activities are tightly regulated, these transcription factors represent highly desirable and logical points of therapeutical interference in cancer development and progression. Three major families of transcription factors have emerged as important players in human cancer and are validated targets in drug discovery for cancer therapy: 1) the NF-kB and AP-1 families of transcription factors, 2) the STAT family members and 3) the steroids receptors. This review aims to elucidate the divergent molecular mechanisms involved in the deregulated activation of transcription factor signaling in malignant transformation, although additional transcription factor families such as the Ets factors, ATF family members, basic helix-loophelix transcription factors etc. are additional critical transcriptional regulators in human cancer. We explore new approaches to specifically inhibit these transcription factors in cancer in order to validate them as a drug targets. Efforts to develop novel viral vectors for therapeutic applications are also discussed. Keywords: Transcription factors, apoptosis, cancer" @default.
• W2083992760 created "2016-06-24" @default.
• W2083992760 creator A5028697843 @default.
• W2083992760 creator A5082987136 @default.
• W2083992760 date "2006-02-01" @default.
• W2083992760 modified "2023-09-25" @default.
• W2083992760 title "Targeting Transcription Factors for Cancer Gene Therapy" @default.
• W2083992760 cites W1491979926 @default.
• W2083992760 cites W1492606093 @default.
• W2083992760 cites W1509401342 @default.
• W2083992760 cites W1512072225 @default.
• W2083992760 cites W1534571605 @default.
• W2083992760 cites W1563090311 @default.
• W2083992760 cites W1568907830 @default.
• W2083992760 cites W1639582946 @default.
• W2083992760 cites W1647075334 @default.
• W2083992760 cites W1821858011 @default.
• W2083992760 cites W1866839234 @default.
• W2083992760 cites W1917630072 @default.
• W2083992760 cites W192503831 @default.
• W2083992760 cites W19330912 @default.
• W2083992760 cites W1967004332 @default.
• W2083992760 cites W1968867081 @default.
• W2083992760 cites W1969158591 @default.
• W2083992760 cites W1971537607 @default.
• W2083992760 cites W1972021050 @default.
• W2083992760 cites W1975426912 @default.
• W2083992760 cites W1978937944 @default.
• W2083992760 cites W1980480652 @default.
• W2083992760 cites W1982062664 @default.
• W2083992760 cites W1983060527 @default.
• W2083992760 cites W1983398917 @default.
• W2083992760 cites W1984564315 @default.
• W2083992760 cites W1984998883 @default.
• W2083992760 cites W1986135678 @default.
• W2083992760 cites W1986832739 @default.
• W2083992760 cites W1987453246 @default.
• W2083992760 cites W1989257894 @default.
• W2083992760 cites W1991868611 @default.
• W2083992760 cites W1994219871 @default.
• W2083992760 cites W1995997868 @default.
• W2083992760 cites W1996112634 @default.
• W2083992760 cites W1997006452 @default.
• W2083992760 cites W1998391516 @default.
• W2083992760 cites W2001825870 @default.
• W2083992760 cites W2001836007 @default.
• W2083992760 cites W2003124067 @default.
• W2083992760 cites W2006273833 @default.
• W2083992760 cites W2009548698 @default.
• W2083992760 cites W2009996294 @default.
• W2083992760 cites W2015788325 @default.
• W2083992760 cites W2016116775 @default.
• W2083992760 cites W2020140319 @default.
• W2083992760 cites W2024282024 @default.
• W2083992760 cites W2027686496 @default.
• W2083992760 cites W2032674547 @default.
• W2083992760 cites W2033758838 @default.
• W2083992760 cites W2034384400 @default.
• W2083992760 cites W2034558617 @default.
• W2083992760 cites W2034753014 @default.
• W2083992760 cites W2035179289 @default.
• W2083992760 cites W2035967893 @default.
• W2083992760 cites W2036702562 @default.
• W2083992760 cites W2037405524 @default.
• W2083992760 cites W2038301672 @default.
• W2083992760 cites W2040703859 @default.
• W2083992760 cites W2041186477 @default.
• W2083992760 cites W2042087846 @default.
• W2083992760 cites W2043051921 @default.
• W2083992760 cites W2047470411 @default.
• W2083992760 cites W2048931400 @default.
• W2083992760 cites W2050066317 @default.
• W2083992760 cites W2050347642 @default.
• W2083992760 cites W2051994734 @default.
• W2083992760 cites W2052312685 @default.
• W2083992760 cites W2052665473 @default.
• W2083992760 cites W2053338574 @default.
• W2083992760 cites W2053535211 @default.
• W2083992760 cites W2055878807 @default.
• W2083992760 cites W2056372829 @default.
• W2083992760 cites W2061485338 @default.
• W2083992760 cites W2062032920 @default.
• W2083992760 cites W2065257477 @default.
• W2083992760 cites W2066456350 @default.
• W2083992760 cites W2069532898 @default.
• W2083992760 cites W2071123815 @default.
• W2083992760 cites W2072319964 @default.
• W2083992760 cites W2075601071 @default.
• W2083992760 cites W2079715612 @default.
• W2083992760 cites W2081491080 @default.
• W2083992760 cites W2082408605 @default.
• W2083992760 cites W2083802827 @default.
• W2083992760 cites W2083906562 @default.
• W2083992760 cites W2084995568 @default.
• W2083992760 cites W2085807801 @default.
• W2083992760 cites W2087287360 @default.
• W2083992760 cites W2087366081 @default.
• W2083992760 cites W2091695331 @default.

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