FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083993851> ?p ?o ?g. }

• W2083993851 endingPage "304" @default.
• W2083993851 startingPage "299" @default.
• W2083993851 abstract "Most correlations between in vitro and in vivo data (IVIVC) rely on linear relationships. However, non-linear IVIVC can be also observed, justified and validated. The purpose of the present work was the development of a methodology for power law IVIVC, which mirror power law kinetics under in vitro and in vivo conditions. Fractional calculus was used to justify power law kinetics for zero-order processes in disordered media. Power law kinetics was observed in a large number of in vitro data sets. When zero-order release and absorption is considered in terms of fractional calculus the following power law IVIVC between the fraction released F(r) and the fraction absorbed F(a), is obtained: F(a)=microF(r)(lambda)-beta, where mu is a constant related to the rate constants and the orders of the release/absorption kinetics, lambda is the ratio of the orders of the kinetics under in vitro and in vivo conditions and beta accounts for a time shift between the in vitro and in vivo processes; We used literature data to develop power law IVIVC and derive estimates for mu, lambda and beta; the simulated pharmacokinetic profiles using the in vitro release data and the IVIVC developed compared well with the actual in vivo data." @default.
• W2083993851 created "2016-06-24" @default.
• W2083993851 creator A5010592110 @default.
• W2083993851 creator A5046045274 @default.
• W2083993851 creator A5079094792 @default.
• W2083993851 date "2010-10-01" @default.
• W2083993851 modified "2023-10-12" @default.
• W2083993851 title "Power law IVIVC: An application of fractional kinetics for drug release and absorption" @default.
• W2083993851 cites W1481809741 @default.
• W2083993851 cites W1483889730 @default.
• W2083993851 cites W1501546570 @default.
• W2083993851 cites W1522767714 @default.
• W2083993851 cites W1603855465 @default.
• W2083993851 cites W186793691 @default.
• W2083993851 cites W1967883258 @default.
• W2083993851 cites W1968729081 @default.
• W2083993851 cites W1969911700 @default.
• W2083993851 cites W1972447012 @default.
• W2083993851 cites W1973487959 @default.
• W2083993851 cites W1973488204 @default.
• W2083993851 cites W1983473009 @default.
• W2083993851 cites W1989290224 @default.
• W2083993851 cites W1995656807 @default.
• W2083993851 cites W1996395903 @default.
• W2083993851 cites W2001509015 @default.
• W2083993851 cites W2002150111 @default.
• W2083993851 cites W2015075381 @default.
• W2083993851 cites W2015142906 @default.
• W2083993851 cites W201758095 @default.
• W2083993851 cites W2022201144 @default.
• W2083993851 cites W2026259404 @default.
• W2083993851 cites W2027096073 @default.
• W2083993851 cites W2030951340 @default.
• W2083993851 cites W2031235210 @default.
• W2083993851 cites W2034387539 @default.
• W2083993851 cites W2034391690 @default.
• W2083993851 cites W2038810336 @default.
• W2083993851 cites W2039728900 @default.
• W2083993851 cites W2039758310 @default.
• W2083993851 cites W2041300691 @default.
• W2083993851 cites W2048910962 @default.
• W2083993851 cites W2053153091 @default.
• W2083993851 cites W2056263862 @default.
• W2083993851 cites W2059789330 @default.
• W2083993851 cites W2060257705 @default.
• W2083993851 cites W2060303523 @default.
• W2083993851 cites W2060320802 @default.
• W2083993851 cites W2065202414 @default.
• W2083993851 cites W2069620374 @default.
• W2083993851 cites W2073655225 @default.
• W2083993851 cites W2079407952 @default.
• W2083993851 cites W2080196464 @default.
• W2083993851 cites W2085909836 @default.
• W2083993851 cites W2086322514 @default.
• W2083993851 cites W2090769267 @default.
• W2083993851 cites W2090934679 @default.
• W2083993851 cites W2091847420 @default.
• W2083993851 cites W2092531169 @default.
• W2083993851 cites W2111271983 @default.
• W2083993851 cites W2115679418 @default.
• W2083993851 cites W2116182190 @default.
• W2083993851 cites W2124084576 @default.
• W2083993851 cites W2144452156 @default.
• W2083993851 cites W2152951429 @default.
• W2083993851 cites W2160273379 @default.
• W2083993851 cites W2160367164 @default.
• W2083993851 cites W4234935292 @default.
• W2083993851 cites W4238663582 @default.
• W2083993851 cites W4250515647 @default.
• W2083993851 cites W69423106 @default.
• W2083993851 cites W1971123897 @default.
• W2083993851 doi "https://doi.org/10.1016/j.ejps.2010.06.015" @default.
• W2083993851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20599504" @default.
• W2083993851 hasPublicationYear "2010" @default.
• W2083993851 type Work @default.
• W2083993851 sameAs 2083993851 @default.
• W2083993851 citedByCount "45" @default.
• W2083993851 countsByYear W20839938512012 @default.
• W2083993851 countsByYear W20839938512013 @default.
• W2083993851 countsByYear W20839938512014 @default.
• W2083993851 countsByYear W20839938512015 @default.
• W2083993851 countsByYear W20839938512016 @default.
• W2083993851 countsByYear W20839938512017 @default.
• W2083993851 countsByYear W20839938512018 @default.
• W2083993851 countsByYear W20839938512019 @default.
• W2083993851 countsByYear W20839938512020 @default.
• W2083993851 countsByYear W20839938512021 @default.
• W2083993851 countsByYear W20839938512022 @default.
• W2083993851 countsByYear W20839938512023 @default.
• W2083993851 crossrefType "journal-article" @default.
• W2083993851 hasAuthorship W2083993851A5010592110 @default.
• W2083993851 hasAuthorship W2083993851A5046045274 @default.
• W2083993851 hasAuthorship W2083993851A5079094792 @default.
• W2083993851 hasConcept C112705442 @default.
• W2083993851 hasConcept C120665830 @default.
• W2083993851 hasConcept C121332964 @default.
• W2083993851 hasConcept C125287762 @default.
• W2083993851 hasConcept C14029885 @default.

• next