FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083995764> ?p ?o ?g. }

• W2083995764 endingPage "635" @default.
• W2083995764 startingPage "623" @default.
• W2083995764 abstract "Neuronal precursor proliferation and axodendritic outgrowth have been regarded as strictly sequential, with process formation presumably beginning after mitotic activity ceases. We now report that sympathetic precursors in vitro often elaborate long neurites before dividing. Of 437 neuroblasts observed in 48 time-lapse recordings, 42 neuroblasts divided. Thirty (71%) of these mitotic neuroblasts had neurites prior to cytokinesis. “Paramitotic” neurites were found to contain microtubules (MTs), indicating that precursors elaborate neuritic cytoskeleton during proliferation. Remarkably, the precise neuritic pattern exhibited by parental neuroblasts was consistently reproduced by daughter cell pairs. Preservation of neuritic morphology occurred through asymmetric division, with individual neurites allocated to specific daughter cells. Paramitotic neurites either remained intact throughout mitosis (12 of 65), or “retracted” into the soma during prophase and then “regrew” within minutes after cytokinesis (53 of 65). “Retraction” and “regrowth” involved resorption of cytoplasm into the soma, then refilling of residual cell membrane, resulting in recapitulation of the parental neurite pattern. Paramitotic neuritogenesis appears to be intrinsically driven, but is responsive to environmental signals. The culture substrate influenced neurite length, but not the response of paramitotic neurites during mitosis or the preservation of neuritic morphology. However, the incidence of neurite-bearing neuroblasts increased from 38 ± 1.3% to 94 ± 1.1% with growth factor treatment. The surprisingly high incidence of paramitotic neurites and the fidelity with which patterning was conserved across cell generations raise the possibility that mitotic precursors engage in pathfinding. Our studies suggest a novel link between neurogenesis and cytoarchitectonic patterning. © 1996 Wiley-Liss, Inc." @default.
• W2083995764 created "2016-06-24" @default.
• W2083995764 creator A5026655827 @default.
• W2083995764 creator A5029610565 @default.
• W2083995764 creator A5077746312 @default.
• W2083995764 date "1996-04-15" @default.
• W2083995764 modified "2023-10-03" @default.
• W2083995764 title "Mitotic neuroblasts determine neuritic patterning of progeny" @default.
• W2083995764 cites W1485241464 @default.
• W2083995764 cites W1489696679 @default.
• W2083995764 cites W1554920990 @default.
• W2083995764 cites W1585284682 @default.
• W2083995764 cites W1978505405 @default.
• W2083995764 cites W1979761504 @default.
• W2083995764 cites W1984834458 @default.
• W2083995764 cites W1985028563 @default.
• W2083995764 cites W1985499212 @default.
• W2083995764 cites W1985994139 @default.
• W2083995764 cites W1993894835 @default.
• W2083995764 cites W1996734367 @default.
• W2083995764 cites W1998298207 @default.
• W2083995764 cites W2000998644 @default.
• W2083995764 cites W2005500113 @default.
• W2083995764 cites W2005672028 @default.
• W2083995764 cites W2007828663 @default.
• W2083995764 cites W2008665164 @default.
• W2083995764 cites W2009896119 @default.
• W2083995764 cites W2014287288 @default.
• W2083995764 cites W2019618246 @default.
• W2083995764 cites W2019864299 @default.
• W2083995764 cites W2024520366 @default.
• W2083995764 cites W2024918105 @default.
• W2083995764 cites W2030275112 @default.
• W2083995764 cites W2031419550 @default.
• W2083995764 cites W2051215942 @default.
• W2083995764 cites W2053468858 @default.
• W2083995764 cites W2060645534 @default.
• W2083995764 cites W2061073224 @default.
• W2083995764 cites W2070135356 @default.
• W2083995764 cites W2070476244 @default.
• W2083995764 cites W2080716529 @default.
• W2083995764 cites W2081740884 @default.
• W2083995764 cites W2086325450 @default.
• W2083995764 cites W2102370254 @default.
• W2083995764 cites W2107035187 @default.
• W2083995764 cites W2118742421 @default.
• W2083995764 cites W2122884624 @default.
• W2083995764 cites W2126984698 @default.
• W2083995764 cites W2131832714 @default.
• W2083995764 cites W2132259160 @default.
• W2083995764 cites W2138099666 @default.
• W2083995764 cites W2138559670 @default.
• W2083995764 cites W2158888445 @default.
• W2083995764 cites W2178522090 @default.
• W2083995764 cites W244008954 @default.
• W2083995764 cites W4238839969 @default.
• W2083995764 cites W4256091752 @default.
• W2083995764 doi "https://doi.org/10.1002/(sici)1096-9861(19960415)367:4<623::aid-cne11>3.0.co;2-i" @default.
• W2083995764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8731230" @default.
• W2083995764 hasPublicationYear "1996" @default.
• W2083995764 type Work @default.
• W2083995764 sameAs 2083995764 @default.
• W2083995764 citedByCount "11" @default.
• W2083995764 crossrefType "journal-article" @default.
• W2083995764 hasAuthorship W2083995764A5026655827 @default.
• W2083995764 hasAuthorship W2083995764A5029610565 @default.
• W2083995764 hasAuthorship W2083995764A5077746312 @default.
• W2083995764 hasConcept C113246987 @default.
• W2083995764 hasConcept C1491633281 @default.
• W2083995764 hasConcept C169760540 @default.
• W2083995764 hasConcept C202751555 @default.
• W2083995764 hasConcept C39961270 @default.
• W2083995764 hasConcept C45472230 @default.
• W2083995764 hasConcept C4746552 @default.
• W2083995764 hasConcept C54355233 @default.
• W2083995764 hasConcept C85813293 @default.
• W2083995764 hasConcept C86803240 @default.
• W2083995764 hasConcept C93304396 @default.
• W2083995764 hasConcept C95444343 @default.
• W2083995764 hasConceptScore W2083995764C113246987 @default.
• W2083995764 hasConceptScore W2083995764C1491633281 @default.
• W2083995764 hasConceptScore W2083995764C169760540 @default.
• W2083995764 hasConceptScore W2083995764C202751555 @default.
• W2083995764 hasConceptScore W2083995764C39961270 @default.
• W2083995764 hasConceptScore W2083995764C45472230 @default.
• W2083995764 hasConceptScore W2083995764C4746552 @default.
• W2083995764 hasConceptScore W2083995764C54355233 @default.
• W2083995764 hasConceptScore W2083995764C85813293 @default.
• W2083995764 hasConceptScore W2083995764C86803240 @default.
• W2083995764 hasConceptScore W2083995764C93304396 @default.
• W2083995764 hasConceptScore W2083995764C95444343 @default.
• W2083995764 hasIssue "4" @default.
• W2083995764 hasLocation W20839957641 @default.
• W2083995764 hasLocation W20839957642 @default.
• W2083995764 hasOpenAccess W2083995764 @default.
• W2083995764 hasPrimaryLocation W20839957641 @default.
• W2083995764 hasRelatedWork W1973375714 @default.
• W2083995764 hasRelatedWork W2062625043 @default.

• next