FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084019898> ?p ?o ?g. }

• W2084019898 endingPage "1039" @default.
• W2084019898 startingPage "1031" @default.
• W2084019898 abstract "The retention of lipoproteins in the arterial intima is an initial event in early atherosclerosis and occurs, in part, through interactions between negatively charged glycosaminoglycans (GAGs) and the positively charged residues of apolipoproteins. Smooth muscle cells (SMCs) which infiltrate into the lipoprotein-enriched intima have been observed to transform into lipid-laden foam cells. This phenotypic switch is associated with SMC acquisition of a macrophage-like capacity to phagocytose lipoproteins and/or of an adipocyte-like capacity to synthesize fatty acids de novo. The aim of the present work was to explore the impact of GAG identity on SMC foam cell formation using a scaffold environment intended to be mimetic of early atherosclerosis. In these studies, we focused on chondroitin sulfate C (CSC), dermatan sulfate (DS), and an intermediate molecular weight hyaluronan (HAIMW, ∼400 kDa), the levels and/or distribution of each of which are significantly altered in atherosclerosis. DS hydrogels were associated with greater SMC phagocytosis of apolipoprotein B than HAIMW gels. Similarly, only SMCs in DS constructs maintained increased expression of the adipocyte marker A-FABP relative to HAIMW gels over 35 days of culture. The increased SMC foam cell phenotype in DS hydrogels was reflected in a corresponding decrease in SMC myosin heavy chain expression in these constructs relative to HAIMW gels at day 35. In addition, this DS-associated increase in foam cell formation was mirrored in an increased SMC synthetic phenotype, as evidenced by greater levels of collagen type I and glucose 6-phosphate dehydrogenase in DS gels than in HAIMW gels. Combined, these results support the increasing body of literature that suggests a critical role for DS-bearing proteoglycans in early atherosclerosis." @default.
• W2084019898 created "2016-06-24" @default.
• W2084019898 creator A5003023331 @default.
• W2084019898 creator A5006630138 @default.
• W2084019898 creator A5017298323 @default.
• W2084019898 creator A5027029728 @default.
• W2084019898 creator A5044710928 @default.
• W2084019898 creator A5044930038 @default.
• W2084019898 creator A5050683736 @default.
• W2084019898 creator A5062838229 @default.
• W2084019898 creator A5070985327 @default.
• W2084019898 creator A5091151089 @default.
• W2084019898 date "2011-03-01" @default.
• W2084019898 modified "2023-10-18" @default.
• W2084019898 title "Regulation of smooth muscle cell phenotype by glycosaminoglycan identity" @default.
• W2084019898 cites W1558409462 @default.
• W2084019898 cites W17602763 @default.
• W2084019898 cites W1965843169 @default.
• W2084019898 cites W1968171440 @default.
• W2084019898 cites W1972278871 @default.
• W2084019898 cites W1974308922 @default.
• W2084019898 cites W1978969388 @default.
• W2084019898 cites W1982280499 @default.
• W2084019898 cites W1983053171 @default.
• W2084019898 cites W1987664863 @default.
• W2084019898 cites W1997544440 @default.
• W2084019898 cites W2000566731 @default.
• W2084019898 cites W2004422976 @default.
• W2084019898 cites W2006008435 @default.
• W2084019898 cites W2013429774 @default.
• W2084019898 cites W2016832000 @default.
• W2084019898 cites W2019405824 @default.
• W2084019898 cites W2020919394 @default.
• W2084019898 cites W2022689478 @default.
• W2084019898 cites W2026752436 @default.
• W2084019898 cites W2027980046 @default.
• W2084019898 cites W2032936734 @default.
• W2084019898 cites W2033589357 @default.
• W2084019898 cites W2034950506 @default.
• W2084019898 cites W2036521370 @default.
• W2084019898 cites W2036954174 @default.
• W2084019898 cites W2043350083 @default.
• W2084019898 cites W2043669923 @default.
• W2084019898 cites W2049023621 @default.
• W2084019898 cites W2058977087 @default.
• W2084019898 cites W2059318458 @default.
• W2084019898 cites W2060877214 @default.
• W2084019898 cites W2070050615 @default.
• W2084019898 cites W2072333923 @default.
• W2084019898 cites W2080697639 @default.
• W2084019898 cites W2087915712 @default.
• W2084019898 cites W2090126495 @default.
• W2084019898 cites W2090930052 @default.
• W2084019898 cites W2091368174 @default.
• W2084019898 cites W2092389312 @default.
• W2084019898 cites W2093181404 @default.
• W2084019898 cites W2094069558 @default.
• W2084019898 cites W2097159801 @default.
• W2084019898 cites W2106225325 @default.
• W2084019898 cites W2114684608 @default.
• W2084019898 cites W2126364995 @default.
• W2084019898 cites W2128534413 @default.
• W2084019898 cites W2129028207 @default.
• W2084019898 cites W2130049306 @default.
• W2084019898 cites W2130606072 @default.
• W2084019898 cites W2138063219 @default.
• W2084019898 cites W2146844497 @default.
• W2084019898 cites W2150750426 @default.
• W2084019898 cites W2152745230 @default.
• W2084019898 cites W2158078705 @default.
• W2084019898 cites W2159992113 @default.
• W2084019898 cites W2162076450 @default.
• W2084019898 cites W2164461910 @default.
• W2084019898 cites W2164880987 @default.
• W2084019898 cites W2169783291 @default.
• W2084019898 doi "https://doi.org/10.1016/j.actbio.2010.11.020" @default.
• W2084019898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21094702" @default.
• W2084019898 hasPublicationYear "2011" @default.
• W2084019898 type Work @default.
• W2084019898 sameAs 2084019898 @default.
• W2084019898 citedByCount "7" @default.
• W2084019898 countsByYear W20840198982012 @default.
• W2084019898 countsByYear W20840198982013 @default.
• W2084019898 countsByYear W20840198982014 @default.
• W2084019898 countsByYear W20840198982018 @default.
• W2084019898 crossrefType "journal-article" @default.
• W2084019898 hasAuthorship W2084019898A5003023331 @default.
• W2084019898 hasAuthorship W2084019898A5006630138 @default.
• W2084019898 hasAuthorship W2084019898A5017298323 @default.
• W2084019898 hasAuthorship W2084019898A5027029728 @default.
• W2084019898 hasAuthorship W2084019898A5044710928 @default.
• W2084019898 hasAuthorship W2084019898A5044930038 @default.
• W2084019898 hasAuthorship W2084019898A5050683736 @default.
• W2084019898 hasAuthorship W2084019898A5062838229 @default.
• W2084019898 hasAuthorship W2084019898A5070985327 @default.
• W2084019898 hasAuthorship W2084019898A5091151089 @default.
• W2084019898 hasConcept C104317684 @default.
• W2084019898 hasConcept C127716648 @default.

• next