Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084037504> ?p ?o ?g. }
- W2084037504 endingPage "1342" @default.
- W2084037504 startingPage "1334" @default.
- W2084037504 abstract "N(G), N(G)-Dimethyl-L-arginine (asymmetric dimethylarginine: ADMA) is an endogenous competitive inhibitor of nitric oxide synthase (NOS). Plasma ADMA concentrations have been reported to increase in connection with diseases associated with an impaired endothelial L-arginine/NO pathway. In this study, we investigated the metabolism of ADMA in circulating blood cell populations to elucidate the regulatory mechanism of elevation of plasma ADMA, a novel risk factor for cardiovascular disease. We found by RT-PCR and Western blot analyses that protein arginine methyltransferase (PRMT)1 and dimethylarginine dimethylaminohydrolase (DDAH)-1, responsible for the biosynthesis and degradation of ADMA respectively, are expressed in erythrocytes (ECs), leukocytes, and platelets. We also identified a major ADMA-containing protein in ECs as catalase, confirmed by GST-pull down assay to bind to PRMT1 in vitro. This is the first report that the ADMA-metabolizing system, including the arginine methylation of proteins and the breakdown of free ADMA, occurs in circulating blood cell-populations, and that catalase in ECs might be a potential protein targeted by PRMT1." @default.
- W2084037504 created "2016-06-24" @default.
- W2084037504 creator A5020475566 @default.
- W2084037504 creator A5032100873 @default.
- W2084037504 creator A5032957138 @default.
- W2084037504 creator A5035513520 @default.
- W2084037504 creator A5070628886 @default.
- W2084037504 creator A5082314901 @default.
- W2084037504 creator A5083663974 @default.
- W2084037504 creator A5087836782 @default.
- W2084037504 date "2012-07-23" @default.
- W2084037504 modified "2023-10-12" @default.
- W2084037504 title "Asymmetric Dimethylarginine, an Endogenous NOS Inhibitor, Is Actively Metabolized in Rat Erythrocytes" @default.
- W2084037504 cites W1583601846 @default.
- W2084037504 cites W1594268419 @default.
- W2084037504 cites W1963559299 @default.
- W2084037504 cites W1969653948 @default.
- W2084037504 cites W1971746374 @default.
- W2084037504 cites W1973291088 @default.
- W2084037504 cites W1974332277 @default.
- W2084037504 cites W1976851726 @default.
- W2084037504 cites W1981098799 @default.
- W2084037504 cites W1989368997 @default.
- W2084037504 cites W2003083382 @default.
- W2084037504 cites W2004417257 @default.
- W2084037504 cites W2008536659 @default.
- W2084037504 cites W2012582516 @default.
- W2084037504 cites W2025347753 @default.
- W2084037504 cites W2030477074 @default.
- W2084037504 cites W2031796832 @default.
- W2084037504 cites W2039741344 @default.
- W2084037504 cites W2040643466 @default.
- W2084037504 cites W2042356706 @default.
- W2084037504 cites W2048333869 @default.
- W2084037504 cites W2055133610 @default.
- W2084037504 cites W2055136499 @default.
- W2084037504 cites W2055155126 @default.
- W2084037504 cites W2057999664 @default.
- W2084037504 cites W2062323653 @default.
- W2084037504 cites W2065374983 @default.
- W2084037504 cites W2066547615 @default.
- W2084037504 cites W2073133399 @default.
- W2084037504 cites W2075124894 @default.
- W2084037504 cites W2079670630 @default.
- W2084037504 cites W2092809155 @default.
- W2084037504 cites W2093994279 @default.
- W2084037504 cites W2099957438 @default.
- W2084037504 cites W2100837269 @default.
- W2084037504 cites W2105082749 @default.
- W2084037504 cites W2112635171 @default.
- W2084037504 cites W2120785970 @default.
- W2084037504 cites W2122545929 @default.
- W2084037504 cites W2122559562 @default.
- W2084037504 cites W2126777636 @default.
- W2084037504 cites W2129050578 @default.
- W2084037504 cites W2133371348 @default.
- W2084037504 cites W2142172510 @default.
- W2084037504 cites W2148148435 @default.
- W2084037504 cites W2151554519 @default.
- W2084037504 cites W2153110646 @default.
- W2084037504 cites W2154388708 @default.
- W2084037504 cites W2156211472 @default.
- W2084037504 cites W2166912566 @default.
- W2084037504 cites W2171284332 @default.
- W2084037504 cites W2317362193 @default.
- W2084037504 cites W4240377582 @default.
- W2084037504 doi "https://doi.org/10.1271/bbb.120086" @default.
- W2084037504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22785485" @default.
- W2084037504 hasPublicationYear "2012" @default.
- W2084037504 type Work @default.
- W2084037504 sameAs 2084037504 @default.
- W2084037504 citedByCount "18" @default.
- W2084037504 countsByYear W20840375042013 @default.
- W2084037504 countsByYear W20840375042014 @default.
- W2084037504 countsByYear W20840375042015 @default.
- W2084037504 countsByYear W20840375042017 @default.
- W2084037504 countsByYear W20840375042018 @default.
- W2084037504 countsByYear W20840375042019 @default.
- W2084037504 countsByYear W20840375042020 @default.
- W2084037504 countsByYear W20840375042022 @default.
- W2084037504 crossrefType "journal-article" @default.
- W2084037504 hasAuthorship W2084037504A5020475566 @default.
- W2084037504 hasAuthorship W2084037504A5032100873 @default.
- W2084037504 hasAuthorship W2084037504A5032957138 @default.
- W2084037504 hasAuthorship W2084037504A5035513520 @default.
- W2084037504 hasAuthorship W2084037504A5070628886 @default.
- W2084037504 hasAuthorship W2084037504A5082314901 @default.
- W2084037504 hasAuthorship W2084037504A5083663974 @default.
- W2084037504 hasAuthorship W2084037504A5087836782 @default.
- W2084037504 hasConcept C104317684 @default.
- W2084037504 hasConcept C126322002 @default.
- W2084037504 hasConcept C134018914 @default.
- W2084037504 hasConcept C16613235 @default.
- W2084037504 hasConcept C181199279 @default.
- W2084037504 hasConcept C185592680 @default.
- W2084037504 hasConcept C2776415932 @default.
- W2084037504 hasConcept C2777468819 @default.
- W2084037504 hasConcept C2777622882 @default.