FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084037807> ?p ?o ?g. }

• W2084037807 endingPage "9405" @default.
• W2084037807 startingPage "9395" @default.
• W2084037807 abstract "We recently demonstrated that a linear 18-residue peptide, (KIGAKI)(3)-NH(2), designed to form amphipathic beta-sheet structure when bound to lipid bilayers, possessed potent antimicrobial activity and low hemolytic activity. The ability of (KIGAKI)(3)-NH(2) to induce leakage from lipid vesicles was compared to that of the amphipathic alpha-helical peptide, (KIAGKIA)(3)-NH(2), which had equivalent antimicrobial activity. Significantly, the lytic properties of (KIGAKI)(3)-NH(2) were enhanced for mixed acidic-neutral lipid vesicles containing phosphatidylethanolamine instead of phosphatidylcholine as the neutral component, while the potency of (KIAGKIA)(3)-NH(2) was significantly reduced [Blazyk, J., et al. (2001) J. Biol. Chem. 276, 27899-27906]. In this paper, we measured the lytic properties of these peptides, as well as several fluorescent analogues containing a single tryptophan residue, by monitoring permeability changes in large unilamellar vesicles with varying lipid compositions and in Escherichia coli cells. The binding of these peptides to lipid bilayers with defined compositions was compared using surface plasmon resonance, circular dichroism, and fluorescence spectroscopy. Surprisingly large differences were observed in membrane binding properties, particularly in the case of KIGAKIKWGAKIKIGAKI-NH(2). Since all of these peptides possess the same charge and very similar mean hydrophobicities, the binding data cannot be explained merely in terms of electrostatic and/or hydrophobic interactions. In light of their equivalent antimicrobial and hemolytic potencies, some of these peptides may employ mechanisms beyond simply increasing plasma membrane permeability to exert their lethal effects." @default.
• W2084037807 created "2016-06-24" @default.
• W2084037807 creator A5000134311 @default.
• W2084037807 creator A5012620484 @default.
• W2084037807 creator A5019797643 @default.
• W2084037807 creator A5025936216 @default.
• W2084037807 creator A5028806241 @default.
• W2084037807 creator A5055027645 @default.
• W2084037807 creator A5056192853 @default.
• W2084037807 creator A5087153069 @default.
• W2084037807 date "2003-07-18" @default.
• W2084037807 modified "2023-09-27" @default.
• W2084037807 title "Influence of Tryptophan on Lipid Binding of Linear Amphipathic Cationic Antimicrobial Peptides" @default.
• W2084037807 cites W1556677948 @default.
• W2084037807 cites W1989642335 @default.
• W2084037807 cites W2018332755 @default.
• W2084037807 cites W2076883126 @default.
• W2084037807 cites W2106613961 @default.
• W2084037807 cites W2158789628 @default.
• W2084037807 doi "https://doi.org/10.1021/bi034338s" @default.
• W2084037807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12899626" @default.
• W2084037807 hasPublicationYear "2003" @default.
• W2084037807 type Work @default.
• W2084037807 sameAs 2084037807 @default.
• W2084037807 citedByCount "40" @default.
• W2084037807 countsByYear W20840378072012 @default.
• W2084037807 countsByYear W20840378072013 @default.
• W2084037807 countsByYear W20840378072014 @default.
• W2084037807 countsByYear W20840378072015 @default.
• W2084037807 countsByYear W20840378072018 @default.
• W2084037807 countsByYear W20840378072021 @default.
• W2084037807 crossrefType "journal-article" @default.
• W2084037807 hasAuthorship W2084037807A5000134311 @default.
• W2084037807 hasAuthorship W2084037807A5012620484 @default.
• W2084037807 hasAuthorship W2084037807A5019797643 @default.
• W2084037807 hasAuthorship W2084037807A5025936216 @default.
• W2084037807 hasAuthorship W2084037807A5028806241 @default.
• W2084037807 hasAuthorship W2084037807A5055027645 @default.
• W2084037807 hasAuthorship W2084037807A5056192853 @default.
• W2084037807 hasAuthorship W2084037807A5087153069 @default.
• W2084037807 hasConcept C106847996 @default.
• W2084037807 hasConcept C12554922 @default.
• W2084037807 hasConcept C130316041 @default.
• W2084037807 hasConcept C133571119 @default.
• W2084037807 hasConcept C155672457 @default.
• W2084037807 hasConcept C15920480 @default.
• W2084037807 hasConcept C171250308 @default.
• W2084037807 hasConcept C178790620 @default.
• W2084037807 hasConcept C185592680 @default.
• W2084037807 hasConcept C192562407 @default.
• W2084037807 hasConcept C2776330855 @default.
• W2084037807 hasConcept C2776706248 @default.
• W2084037807 hasConcept C2778001312 @default.
• W2084037807 hasConcept C2778918659 @default.
• W2084037807 hasConcept C2779281246 @default.
• W2084037807 hasConcept C39944091 @default.
• W2084037807 hasConcept C41625074 @default.
• W2084037807 hasConcept C515207424 @default.
• W2084037807 hasConcept C521977710 @default.
• W2084037807 hasConcept C540938839 @default.
• W2084037807 hasConcept C55493867 @default.
• W2084037807 hasConcept C67407626 @default.
• W2084037807 hasConcept C71240020 @default.
• W2084037807 hasConcept C86803240 @default.
• W2084037807 hasConceptScore W2084037807C106847996 @default.
• W2084037807 hasConceptScore W2084037807C12554922 @default.
• W2084037807 hasConceptScore W2084037807C130316041 @default.
• W2084037807 hasConceptScore W2084037807C133571119 @default.
• W2084037807 hasConceptScore W2084037807C155672457 @default.
• W2084037807 hasConceptScore W2084037807C15920480 @default.
• W2084037807 hasConceptScore W2084037807C171250308 @default.
• W2084037807 hasConceptScore W2084037807C178790620 @default.
• W2084037807 hasConceptScore W2084037807C185592680 @default.
• W2084037807 hasConceptScore W2084037807C192562407 @default.
• W2084037807 hasConceptScore W2084037807C2776330855 @default.
• W2084037807 hasConceptScore W2084037807C2776706248 @default.
• W2084037807 hasConceptScore W2084037807C2778001312 @default.
• W2084037807 hasConceptScore W2084037807C2778918659 @default.
• W2084037807 hasConceptScore W2084037807C2779281246 @default.
• W2084037807 hasConceptScore W2084037807C39944091 @default.
• W2084037807 hasConceptScore W2084037807C41625074 @default.
• W2084037807 hasConceptScore W2084037807C515207424 @default.
• W2084037807 hasConceptScore W2084037807C521977710 @default.
• W2084037807 hasConceptScore W2084037807C540938839 @default.
• W2084037807 hasConceptScore W2084037807C55493867 @default.
• W2084037807 hasConceptScore W2084037807C67407626 @default.
• W2084037807 hasConceptScore W2084037807C71240020 @default.
• W2084037807 hasConceptScore W2084037807C86803240 @default.
• W2084037807 hasIssue "31" @default.
• W2084037807 hasLocation W20840378071 @default.
• W2084037807 hasLocation W20840378072 @default.
• W2084037807 hasOpenAccess W2084037807 @default.
• W2084037807 hasPrimaryLocation W20840378071 @default.
• W2084037807 hasRelatedWork W1964058841 @default.
• W2084037807 hasRelatedWork W1965215197 @default.
• W2084037807 hasRelatedWork W1977063081 @default.
• W2084037807 hasRelatedWork W1995470685 @default.
• W2084037807 hasRelatedWork W1998981872 @default.

• next