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- W2084045256 abstract "Abstract The fine structural degeneration of nerves innervating the arterioles of the hamster cheek pouch was examined after exposure to a single intraperitoneal dose of 6-hydroxydopamine (6-OHDA). 4 hr after drug exposure pale and swollen axons with disrupted internal structure were frequently encountered in the vascular adventitia. Other fibers showed an increased density and frequently appeared to contain aggregations of electron dense mitochondria and coagulated vesicles and cytoplasm. By 48 hr many axons had disappeared and others remained only as dense inclusion bodies of Schwann cells. The degeneration appeared to progress from those nerve terminals located near the media toward the preterminal portions of the fibers in the outer adventitia. The susceptibility of the periarteriolar nerves of the hamster cheek pouch to 6-OHDA together with several other properties of this tissue combine to make it a representative microcirculatory bed for the study of the effects of this drug and others on mammalian neurovascular structures." @default.
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- W2084045256 date "1971-08-01" @default.
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- W2084045256 title "Perivascular nerve degeneration produced in the hamster cheek pouch by 6-hydroxydopamine" @default.
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- W2084045256 doi "https://doi.org/10.1016/0014-2999(71)90095-1" @default.
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