Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084049772> ?p ?o ?g. }
- W2084049772 endingPage "9" @default.
- W2084049772 startingPage "1" @default.
- W2084049772 abstract "It has been suggested that superinfection of HIV positive individuals with heterologous HIV strains could lead to faster progression to AIDS, generating concern over the risks of exposure to new infections in those already infected. A mathematical model of the within-host dynamics of two sequential infections with strains of HIV describing activation and infection of immune cells was developed. Multiple stochastic realisations describing progression to AIDS in the individual were generated, comparing the situation with and without superinfection. It was found that the susceptibility of immune cells to dual infection is crucial to the outcome of HIV superinfection. A low susceptibility leads to competitive exclusion between the strains and a high susceptibility may lead to co-existence if the superinfecting strain is sufficiently fit. It was also found that only superinfection with a fitter strain leads to faster progression to AIDS, rather than superinfection per se. In theory, a superinfection event with a heterologous strain of HIV does not lead to faster progression to AIDS. Unless superinfection allows the spread of fitter virus, it should not be of concern for public health." @default.
- W2084049772 created "2016-06-24" @default.
- W2084049772 creator A5002322327 @default.
- W2084049772 creator A5026491769 @default.
- W2084049772 creator A5049260734 @default.
- W2084049772 creator A5062368847 @default.
- W2084049772 creator A5074180439 @default.
- W2084049772 date "2010-03-01" @default.
- W2084049772 modified "2023-09-27" @default.
- W2084049772 title "Superinfection with a heterologous HIV strain per se does not lead to faster progression" @default.
- W2084049772 cites W1509269909 @default.
- W2084049772 cites W1522687244 @default.
- W2084049772 cites W1564649778 @default.
- W2084049772 cites W1963654790 @default.
- W2084049772 cites W1966771136 @default.
- W2084049772 cites W1971577383 @default.
- W2084049772 cites W1974566789 @default.
- W2084049772 cites W1978518017 @default.
- W2084049772 cites W1980441640 @default.
- W2084049772 cites W1981322173 @default.
- W2084049772 cites W1986243552 @default.
- W2084049772 cites W1988374011 @default.
- W2084049772 cites W1991734440 @default.
- W2084049772 cites W1992801522 @default.
- W2084049772 cites W2001800250 @default.
- W2084049772 cites W2002062046 @default.
- W2084049772 cites W2007922771 @default.
- W2084049772 cites W2008799315 @default.
- W2084049772 cites W2014984955 @default.
- W2084049772 cites W2022098233 @default.
- W2084049772 cites W2024976854 @default.
- W2084049772 cites W2027829215 @default.
- W2084049772 cites W2029815847 @default.
- W2084049772 cites W2030856851 @default.
- W2084049772 cites W2037690856 @default.
- W2084049772 cites W2044403736 @default.
- W2084049772 cites W2049203607 @default.
- W2084049772 cites W2051063688 @default.
- W2084049772 cites W2060534902 @default.
- W2084049772 cites W2070362139 @default.
- W2084049772 cites W2076210250 @default.
- W2084049772 cites W2076892180 @default.
- W2084049772 cites W2086616853 @default.
- W2084049772 cites W2088129901 @default.
- W2084049772 cites W2107073197 @default.
- W2084049772 cites W2112329925 @default.
- W2084049772 cites W2112747319 @default.
- W2084049772 cites W2112794619 @default.
- W2084049772 cites W2119867328 @default.
- W2084049772 cites W2122723212 @default.
- W2084049772 cites W2129114331 @default.
- W2084049772 cites W2134892664 @default.
- W2084049772 cites W2135322737 @default.
- W2084049772 cites W2139338553 @default.
- W2084049772 cites W2145283309 @default.
- W2084049772 cites W2147143873 @default.
- W2084049772 cites W2151002451 @default.
- W2084049772 cites W2152626091 @default.
- W2084049772 cites W2153424010 @default.
- W2084049772 cites W2156963508 @default.
- W2084049772 cites W2157051716 @default.
- W2084049772 cites W2161687499 @default.
- W2084049772 cites W2167706591 @default.
- W2084049772 cites W2172023022 @default.
- W2084049772 cites W2314320504 @default.
- W2084049772 cites W2409251092 @default.
- W2084049772 doi "https://doi.org/10.1016/j.mbs.2009.11.007" @default.
- W2084049772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19932122" @default.
- W2084049772 hasPublicationYear "2010" @default.
- W2084049772 type Work @default.
- W2084049772 sameAs 2084049772 @default.
- W2084049772 citedByCount "11" @default.
- W2084049772 countsByYear W20840497722012 @default.
- W2084049772 countsByYear W20840497722013 @default.
- W2084049772 countsByYear W20840497722014 @default.
- W2084049772 countsByYear W20840497722018 @default.
- W2084049772 crossrefType "journal-article" @default.
- W2084049772 hasAuthorship W2084049772A5002322327 @default.
- W2084049772 hasAuthorship W2084049772A5026491769 @default.
- W2084049772 hasAuthorship W2084049772A5049260734 @default.
- W2084049772 hasAuthorship W2084049772A5062368847 @default.
- W2084049772 hasAuthorship W2084049772A5074180439 @default.
- W2084049772 hasConcept C104317684 @default.
- W2084049772 hasConcept C159047783 @default.
- W2084049772 hasConcept C18903297 @default.
- W2084049772 hasConcept C203014093 @default.
- W2084049772 hasConcept C2522874641 @default.
- W2084049772 hasConcept C2779617845 @default.
- W2084049772 hasConcept C2780115692 @default.
- W2084049772 hasConcept C2992687717 @default.
- W2084049772 hasConcept C3013748606 @default.
- W2084049772 hasConcept C54355233 @default.
- W2084049772 hasConcept C86803240 @default.
- W2084049772 hasConcept C8891405 @default.
- W2084049772 hasConcept C91306197 @default.
- W2084049772 hasConceptScore W2084049772C104317684 @default.
- W2084049772 hasConceptScore W2084049772C159047783 @default.
- W2084049772 hasConceptScore W2084049772C18903297 @default.