Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084052898> ?p ?o ?g. }
- W2084052898 endingPage "157" @default.
- W2084052898 startingPage "150" @default.
- W2084052898 abstract "The application of Fourier-transform infrared (FTIR) spectroscopy for the detection of structural disorders in colorectal cancer deoxyribonucleic acid (DNA) has been investigated. The DNA was isolated from cancer and its adjacent histological normal tissue of 43 colorectal cancer patients. Minor structural disorders in cancer DNA were detected by differences in the spectral regions assigned to nucleotide bases and phosphodiester-deoxyribose backbone. Spectral differences between grade 1, 2 and 3 cancers were also observed. Furthermore, the normal DNA spectra from patients above 50 years were observed to exhibit cancer like phenotype. The spectral data were further evaluated using linear discriminant analysis with different leave-n-out cross-validation schemes (up to n = 15) after reducing the number of spectral variables down to nine for classification using a heuristic optimisation procedure. Diagnostic accuracies between 70 and 86% were achieved using different validation strategies, the lowest achieved by using a variable selection scheme independent from the validation test data. For practical work and due to the small sample population studied also prior wavelength selection schemes based on cross-validation using the whole data set were tested leading to more optimistic accuracies. Our findings suggest that mid-infrared spectroscopy can be applied for clinical studies elucidating DNA structure relevance." @default.
- W2084052898 created "2016-06-24" @default.
- W2084052898 creator A5021217013 @default.
- W2084052898 creator A5035137391 @default.
- W2084052898 creator A5062912273 @default.
- W2084052898 creator A5071130903 @default.
- W2084052898 creator A5072097086 @default.
- W2084052898 creator A5087315762 @default.
- W2084052898 date "2008-03-01" @default.
- W2084052898 modified "2023-09-25" @default.
- W2084052898 title "Detection of structural disorders in colorectal cancer DNA with Fourier-transform infrared spectroscopy" @default.
- W2084052898 cites W1587493794 @default.
- W2084052898 cites W162044274 @default.
- W2084052898 cites W1964296429 @default.
- W2084052898 cites W1971056233 @default.
- W2084052898 cites W1973591923 @default.
- W2084052898 cites W1973851905 @default.
- W2084052898 cites W1975374743 @default.
- W2084052898 cites W1988587365 @default.
- W2084052898 cites W1993069380 @default.
- W2084052898 cites W1994116295 @default.
- W2084052898 cites W2001517805 @default.
- W2084052898 cites W2003595062 @default.
- W2084052898 cites W2003857638 @default.
- W2084052898 cites W2004128332 @default.
- W2084052898 cites W2006803829 @default.
- W2084052898 cites W2010900464 @default.
- W2084052898 cites W2010920141 @default.
- W2084052898 cites W2014599678 @default.
- W2084052898 cites W2016533476 @default.
- W2084052898 cites W2016847372 @default.
- W2084052898 cites W2021994434 @default.
- W2084052898 cites W2022857974 @default.
- W2084052898 cites W2024050733 @default.
- W2084052898 cites W2026332374 @default.
- W2084052898 cites W2030530487 @default.
- W2084052898 cites W2032122570 @default.
- W2084052898 cites W2036050531 @default.
- W2084052898 cites W2036528771 @default.
- W2084052898 cites W2039692707 @default.
- W2084052898 cites W2042806265 @default.
- W2084052898 cites W2046911802 @default.
- W2084052898 cites W2064288817 @default.
- W2084052898 cites W2065366305 @default.
- W2084052898 cites W2082896906 @default.
- W2084052898 cites W2083272163 @default.
- W2084052898 cites W2107153148 @default.
- W2084052898 cites W2111558633 @default.
- W2084052898 cites W2114948235 @default.
- W2084052898 cites W2116050737 @default.
- W2084052898 cites W2128709694 @default.
- W2084052898 cites W2129549906 @default.
- W2084052898 cites W2135399477 @default.
- W2084052898 cites W2142773345 @default.
- W2084052898 cites W2165413476 @default.
- W2084052898 cites W2166936616 @default.
- W2084052898 cites W2170666950 @default.
- W2084052898 cites W2324697883 @default.
- W2084052898 doi "https://doi.org/10.1016/j.vibspec.2007.12.010" @default.
- W2084052898 hasPublicationYear "2008" @default.
- W2084052898 type Work @default.
- W2084052898 sameAs 2084052898 @default.
- W2084052898 citedByCount "23" @default.
- W2084052898 countsByYear W20840528982012 @default.
- W2084052898 countsByYear W20840528982013 @default.
- W2084052898 countsByYear W20840528982017 @default.
- W2084052898 countsByYear W20840528982018 @default.
- W2084052898 countsByYear W20840528982019 @default.
- W2084052898 countsByYear W20840528982020 @default.
- W2084052898 countsByYear W20840528982021 @default.
- W2084052898 countsByYear W20840528982022 @default.
- W2084052898 countsByYear W20840528982023 @default.
- W2084052898 crossrefType "journal-article" @default.
- W2084052898 hasAuthorship W2084052898A5021217013 @default.
- W2084052898 hasAuthorship W2084052898A5035137391 @default.
- W2084052898 hasAuthorship W2084052898A5062912273 @default.
- W2084052898 hasAuthorship W2084052898A5071130903 @default.
- W2084052898 hasAuthorship W2084052898A5072097086 @default.
- W2084052898 hasAuthorship W2084052898A5087315762 @default.
- W2084052898 hasConcept C102519508 @default.
- W2084052898 hasConcept C104317684 @default.
- W2084052898 hasConcept C113196181 @default.
- W2084052898 hasConcept C120665830 @default.
- W2084052898 hasConcept C121332964 @default.
- W2084052898 hasConcept C121608353 @default.
- W2084052898 hasConcept C134306372 @default.
- W2084052898 hasConcept C153642686 @default.
- W2084052898 hasConcept C154945302 @default.
- W2084052898 hasConcept C160892712 @default.
- W2084052898 hasConcept C178790620 @default.
- W2084052898 hasConcept C185592680 @default.
- W2084052898 hasConcept C2777709666 @default.
- W2084052898 hasConcept C2908647359 @default.
- W2084052898 hasConcept C33923547 @default.
- W2084052898 hasConcept C38441620 @default.
- W2084052898 hasConcept C41008148 @default.
- W2084052898 hasConcept C43617362 @default.
- W2084052898 hasConcept C46141821 @default.