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• W2084056352 abstract "The neural degeneration caused by spinal cord injury leaves a cavity at the injury site that greatly inhibits repair. One approach to promoting repair is to fill the cavity with a scaffold to limit further damage and encourage regrowth. Injectable materials are advantageous scaffolds because they can be placed as a liquid in the lesion site then form a solid in vivo that precisely matches the contours of the lesion. Fibrin is one type of injectable scaffold, but risk of infection from blood borne pathogens has limited its use. We investigated the potential utility of salmon fibrin as an injectable scaffold to treat spinal cord injury since it lacks mammalian infectious agents and encourages greater neuronal extension in vitro than mammalian fibrin or Matrigel®, another injectable material. Female rats received a T9 dorsal hemisection injury and were treated with either salmon or human fibrin at the time of injury while a third group served as untreated controls. Locomotor function was assessed using the BBB scale, bladder function was analyzed by measuring residual urine, and sensory responses were tested by mechanical stimulation (von Frey hairs). Histological analyses quantified the glial scar, lesion volume, and serotonergic fiber density. Rats that received salmon fibrin exhibited significantly improved recovery of both locomotor and bladder function and a greater density of serotonergic innervation caudal to the lesion site without exacerbation of pain. Rats treated with salmon fibrin also exhibited less autophagia than those treated with human fibrin, potentially pointing to amelioration of sensory dysfunction. Glial scar formation and lesion size did not differ significantly among groups. The pattern and timing of salmon fibrin's effects suggest that it acts on neuronal populations but not by stimulating long tract regeneration. Salmon fibrin clearly has properties distinct from those of mammalian fibrin and is a beneficial injectable scaffold for treatment of spinal cord injury." @default.
• W2084056352 created "2016-06-24" @default.
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• W2084056352 date "2012-05-01" @default.
• W2084056352 modified "2023-10-14" @default.
• W2084056352 title "Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation" @default.
• W2084056352 cites W1580343424 @default.
• W2084056352 cites W1662968076 @default.
• W2084056352 cites W1817027815 @default.
• W2084056352 cites W1963892608 @default.
• W2084056352 cites W1965812618 @default.
• W2084056352 cites W1967599454 @default.
• W2084056352 cites W1968231574 @default.
• W2084056352 cites W1987408946 @default.
• W2084056352 cites W1990228542 @default.
• W2084056352 cites W1996358781 @default.
• W2084056352 cites W1996967454 @default.
• W2084056352 cites W1999735595 @default.
• W2084056352 cites W1999761643 @default.
• W2084056352 cites W2002128589 @default.
• W2084056352 cites W2002558193 @default.
• W2084056352 cites W2004211209 @default.
• W2084056352 cites W2006132770 @default.
• W2084056352 cites W2006862730 @default.
• W2084056352 cites W2009005936 @default.
• W2084056352 cites W2012924135 @default.
• W2084056352 cites W2013152171 @default.
• W2084056352 cites W2014990086 @default.
• W2084056352 cites W2019819594 @default.
• W2084056352 cites W2020655188 @default.
• W2084056352 cites W2021696469 @default.
• W2084056352 cites W2031268185 @default.
• W2084056352 cites W2035023695 @default.
• W2084056352 cites W2036883176 @default.
• W2084056352 cites W2041993072 @default.
• W2084056352 cites W2044137611 @default.
• W2084056352 cites W2055604817 @default.
• W2084056352 cites W2059028717 @default.
• W2084056352 cites W2062436102 @default.
• W2084056352 cites W2063527175 @default.
• W2084056352 cites W2065847096 @default.
• W2084056352 cites W2067422758 @default.
• W2084056352 cites W2069978113 @default.
• W2084056352 cites W2074061676 @default.
• W2084056352 cites W2074173631 @default.
• W2084056352 cites W2074274013 @default.
• W2084056352 cites W2076731990 @default.
• W2084056352 cites W2078132464 @default.
• W2084056352 cites W2083267292 @default.
• W2084056352 cites W2086232800 @default.
• W2084056352 cites W2086819817 @default.
• W2084056352 cites W2087193323 @default.
• W2084056352 cites W2087609924 @default.
• W2084056352 cites W2087887113 @default.
• W2084056352 cites W2089287863 @default.
• W2084056352 cites W2095301611 @default.
• W2084056352 cites W2099399967 @default.
• W2084056352 cites W2104968232 @default.
• W2084056352 cites W2110406916 @default.
• W2084056352 cites W2112390736 @default.
• W2084056352 cites W2119199959 @default.
• W2084056352 cites W2123450039 @default.
• W2084056352 cites W2128638598 @default.
• W2084056352 cites W2128751464 @default.
• W2084056352 cites W2129588435 @default.
• W2084056352 cites W2130153447 @default.
• W2084056352 cites W2135376726 @default.
• W2084056352 cites W2142424019 @default.
• W2084056352 cites W2151426020 @default.
• W2084056352 cites W2156657391 @default.
• W2084056352 cites W2160353065 @default.
• W2084056352 cites W2166607129 @default.
• W2084056352 cites W2167370432 @default.
• W2084056352 cites W2170645579 @default.
• W2084056352 cites W2172201406 @default.
• W2084056352 cites W2243354333 @default.
• W2084056352 cites W4245117410 @default.
• W2084056352 cites W4252930791 @default.
• W2084056352 cites W9064404 @default.
• W2084056352 doi "https://doi.org/10.1016/j.expneurol.2012.02.016" @default.
• W2084056352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3437931" @default.
• W2084056352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22414309" @default.
• W2084056352 hasPublicationYear "2012" @default.
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