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- W2084058465 abstract "The effects of insulin and glucagon on amino acid transport in the regenerating liver were investigated by measuring the uptake of α-aminoisobutyric acid in isolated hepatocytes from partially (70%) hepatectomized rats and from pancreatectomized-partially hepatectomized animals. Partial hepatectomy induced the emergence of a high affinity (Km ≅ 1 mM) transport component in hepatocytes from the liver remnant; in hepatocytes isolated 3, 6, and 16 h after partial hepatectomy, the Vmax (nanomoles per 1066 cells / min) of this component was 2.7 ± 0.3, 4.9 ± 1.0, 5.1 ± 0.9 (mean ± SE), respectively. Combination of pancreatectomy and partial hepatectomy, which resulted in a marked decrease in plasma insulin but not glucagon immunoreactivity, delayed the emergence of the high affinity component and reduced its capacity (Vmax = 1.5 ± 0.5 nmol / 106 cells/min 6 h after operation). Infusion of exogenous insulin in pancreatictomized-partially hepatectomized rats restored the emergence of the high affinity transport c..." @default.
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- W2084058465 date "1981-09-01" @default.
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- W2084058465 title "Effect of Insulin and Glucagon on Amino Acid Transport in Isolated Hepatocytes after Partial Hepatectomy in the Rat*" @default.
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- W2084058465 doi "https://doi.org/10.1210/endo-109-3-868" @default.
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