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- W2084062425 abstract "Invasive aspergillosis is a life-threatening and difficult to treat infection in immunosuppressed patients. The efficacy of current anti-Aspergillus therapies, targeting the cell wall or membrane, is limited by toxicity (polyenes), fungistatic activity and some level of basal resistance (echinocandins), or the emergence of acquired resistance (triazoles). The heat shock protein 90 (Hsp90) is a conserved molecular chaperone involved in the rapid development of antifungal resistance in the yeast Candida albicans. Few studies have addressed its role in filamentous fungi such as Aspergillus fumigatus, in which mechanisms of resistance may differ substantially. Hsp90 is at the center of a complex network involving calcineurin, lysine deacetylases (KDAC) and other client proteins, which orchestrate compensatory repair mechanisms of the cell wall in response to the stress induced by antifungals. In A. fumigatus, Hsp90 is a trigger for resistance to high concentrations of caspofungin, known as the paradoxical effect. Disrupting Hsp90 circuitry by different means (Hsp90 inhibitors, KDAC inhibitors and anti-calcineurin drugs) potentiates the antifungal activity of caspofungin, thus representing a promising novel antifungal approach. This review will discuss the specific features of A. fumigatus Hsp90 and the potential for antifungal strategies of invasive aspergillosis targeting this essential chaperone." @default.
- W2084062425 created "2016-06-24" @default.
- W2084062425 creator A5014148691 @default.
- W2084062425 creator A5015691337 @default.
- W2084062425 creator A5056810823 @default.
- W2084062425 date "2014-09-22" @default.
- W2084062425 modified "2023-10-18" @default.
- W2084062425 title "Heat shock protein 90 (Hsp90): A novel antifungal target against<i>Aspergillus fumigatus</i>" @default.
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- W2084062425 doi "https://doi.org/10.3109/1040841x.2014.947239" @default.
- W2084062425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25243616" @default.
- W2084062425 hasPublicationYear "2014" @default.
- W2084062425 type Work @default.