Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084063517> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2084063517 abstract "Inhibition of platelet aggregation following aspirin ingestion is thought to be overcome by the presence of a small minority of uninhibited platelets. Indeed, it is often quoted that more than 95% of platelets must be inhibited by aspirin for full anti-thrombotic protection.12 Aspirin is an irreversible inhibitor of platelet cyclooxygenase, while the thienopyridines, notably clopidogrel and prasugrel, are irreversible blockers of platelet P2Y12 receptors. In analogy to the effects of aspirin, we have investigated the relationships between the proportion of P2Y12 inhibited platelets and aggregation responses, using the agonists ADP, U46619, TRAP-6 amide and collagen. Platelet rich plasma obtained from healthy volunteers was incubated with either prasugrel-active metabolite (PAM; 3 μM) or vehicle. After washing, different combinations of PAM- and vehicle-treated platelets were transferred to 96-well plates containing fibrinogen (10 μM), CaCl 2 (2 μM) and increasing concentrations of ADP, U46619, TRAP-6 amide or collagen. To follow platelet aggregation, absorbance at 595 nm was measured over 16 min of vigorous shaking. In contrast to studies with aspirin, in this in vitro study we have found a linear relationship between the proportion of P2Y12 receptor uninhibited platelets and aggregation in responses to ADP, U46619 and TRAP-6 amide. As P2Y12 receptor antagonists are almost always used in conjunction with aspirin for anti-thrombotic protection this suggests a complex relationship between proportions of uninhibited platelets and platelet responsiveness which demands further examination, particularly with regard to at risk patient groups." @default.
- W2084063517 created "2016-06-24" @default.
- W2084063517 creator A5002943978 @default.
- W2084063517 creator A5010066823 @default.
- W2084063517 creator A5049732997 @default.
- W2084063517 date "2011-09-23" @default.
- W2084063517 modified "2023-09-27" @default.
- W2084063517 title "12 Relationship between proportions of P2Y12 inhibited platelets and aggregation in vitro" @default.
- W2084063517 cites W2100858861 @default.
- W2084063517 cites W76482949 @default.
- W2084063517 doi "https://doi.org/10.1136/heartjnl-2011-300920b.12" @default.
- W2084063517 hasPublicationYear "2011" @default.
- W2084063517 type Work @default.
- W2084063517 sameAs 2084063517 @default.
- W2084063517 citedByCount "0" @default.
- W2084063517 crossrefType "journal-article" @default.
- W2084063517 hasAuthorship W2084063517A5002943978 @default.
- W2084063517 hasAuthorship W2084063517A5010066823 @default.
- W2084063517 hasAuthorship W2084063517A5049732997 @default.
- W2084063517 hasConcept C12554922 @default.
- W2084063517 hasConcept C126322002 @default.
- W2084063517 hasConcept C185592680 @default.
- W2084063517 hasConcept C2777028646 @default.
- W2084063517 hasConcept C2777399203 @default.
- W2084063517 hasConcept C2777628954 @default.
- W2084063517 hasConcept C2777849778 @default.
- W2084063517 hasConcept C2993802102 @default.
- W2084063517 hasConcept C3018697912 @default.
- W2084063517 hasConcept C49059817 @default.
- W2084063517 hasConcept C55493867 @default.
- W2084063517 hasConcept C71924100 @default.
- W2084063517 hasConcept C86803240 @default.
- W2084063517 hasConcept C89560881 @default.
- W2084063517 hasConcept C98274493 @default.
- W2084063517 hasConceptScore W2084063517C12554922 @default.
- W2084063517 hasConceptScore W2084063517C126322002 @default.
- W2084063517 hasConceptScore W2084063517C185592680 @default.
- W2084063517 hasConceptScore W2084063517C2777028646 @default.
- W2084063517 hasConceptScore W2084063517C2777399203 @default.
- W2084063517 hasConceptScore W2084063517C2777628954 @default.
- W2084063517 hasConceptScore W2084063517C2777849778 @default.
- W2084063517 hasConceptScore W2084063517C2993802102 @default.
- W2084063517 hasConceptScore W2084063517C3018697912 @default.
- W2084063517 hasConceptScore W2084063517C49059817 @default.
- W2084063517 hasConceptScore W2084063517C55493867 @default.
- W2084063517 hasConceptScore W2084063517C71924100 @default.
- W2084063517 hasConceptScore W2084063517C86803240 @default.
- W2084063517 hasConceptScore W2084063517C89560881 @default.
- W2084063517 hasConceptScore W2084063517C98274493 @default.
- W2084063517 hasLocation W20840635171 @default.
- W2084063517 hasOpenAccess W2084063517 @default.
- W2084063517 hasPrimaryLocation W20840635171 @default.
- W2084063517 hasRelatedWork W118034933 @default.
- W2084063517 hasRelatedWork W1490975006 @default.
- W2084063517 hasRelatedWork W1548409037 @default.
- W2084063517 hasRelatedWork W1930503019 @default.
- W2084063517 hasRelatedWork W1992447985 @default.
- W2084063517 hasRelatedWork W2010950088 @default.
- W2084063517 hasRelatedWork W2018335796 @default.
- W2084063517 hasRelatedWork W2030353579 @default.
- W2084063517 hasRelatedWork W2032766983 @default.
- W2084063517 hasRelatedWork W2037116480 @default.
- W2084063517 hasRelatedWork W2070352153 @default.
- W2084063517 hasRelatedWork W2079708561 @default.
- W2084063517 hasRelatedWork W2105735830 @default.
- W2084063517 hasRelatedWork W2124831319 @default.
- W2084063517 hasRelatedWork W2164511280 @default.
- W2084063517 hasRelatedWork W2290232366 @default.
- W2084063517 hasRelatedWork W2313501074 @default.
- W2084063517 hasRelatedWork W2379690980 @default.
- W2084063517 hasRelatedWork W2417646536 @default.
- W2084063517 hasRelatedWork W2096821978 @default.
- W2084063517 isParatext "false" @default.
- W2084063517 isRetracted "false" @default.
- W2084063517 magId "2084063517" @default.
- W2084063517 workType "article" @default.