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- W2084073662 abstract "Dans les cancers du canal anal, depuis les travaux de Nigro, le protocole de chimiothérapie par 5-fluoro-uracile et mitomycine C est utilisé de façon standard en association avec la radiothérapie. La chirurgie est réservée aux échecs de la radiothérapie. Deux essais randomisés européens (EORTC, UKCCCR) ont montré que ce protocole améliorait le contrôle local sans gain de survie par rapport à l'irradiation seule. L'analyse du protocole du RTOC-ECOG a montré que la mitomycine C améliorait le contrôle local par rapport au 5-fluoro-uracile seul. Cette chimiothérapie peut entraîner un décès iatrogène dans 2 % des cas. Il est possible que le protocole 5-fluoro-uracile-cisplatine représente une alternative à l'association 5-fluoro-uracile-mitomycine C. Des essais en cours répondront à cette question. In the treatment of anal canal carcinoma, since the work of Nigro, the 5-fluorouracil-mitomycin C regimen is considered standard when applied concomitently with radiotherapy. Surgery is used mainly to salvage the failures after irradiation. Two randomized European trials (EORTC, UKCCCR) have shown that the 5-fluorouracil-mitomycin C combination improves local control but not overall survival. The RTOC-ECOG trial has shown that mitomycin C improves local control when compared to 5-fluorouracil alone. This chemotherapy is responsible for a toxic death in 2% of cases. The 5-fluorouracil-cisplatin regimen will posibly represent an alternative to the 5-fluorouracil-mitomycin C. Ongoing trials will help to answer this question." @default.
- W2084073662 created "2016-06-24" @default.
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- W2084073662 date "1998-12-01" @default.
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- W2084073662 title "La chimioradiothérapie dans le traitement du cancer du canal anal" @default.
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- W2084073662 doi "https://doi.org/10.1016/s1278-3218(99)80012-2" @default.
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