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- W2084077648 abstract "The diene system of 1α,25-dihydroxy-19-norvitamin D 3 was replaced by a stable amide bond. A 3-hydroxypropoxy group, which was effective on enhancing binding affinity of 1α,25-dihydroxyvitamin D 3 for vitamin D receptor (VDR), was introduced to the C2-position of the amide type analogue of 1α,25-dihydroxy-19-norvitamin D 3 . The amide analogue was found to be not suitable for binding to the ligand binding domain of the bovine thymus VDR, and additional modification at the C2-position did not improve the affinity. Potency in induction of HL-60 cell differentiation was evaluated for the novel amide analogues (3a-c)." @default.
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- W2084077648 date "2004-01-01" @default.
- W2084077648 modified "2023-10-09" @default.
- W2084077648 title "Synthesis of Novel 1a,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate" @default.
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- W2084077648 doi "https://doi.org/10.3987/com-03-s(p)34" @default.
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