Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084080552> ?p ?o ?g. }
- W2084080552 endingPage "135" @default.
- W2084080552 startingPage "123" @default.
- W2084080552 abstract "Axon-dendrite polarity is a cardinal feature of neuronal morphology essential for information flow. Here we report a differential distribution of GSK-3β activity in the axon versus the dendrites. A constitutively active GSK-3β mutant inhibited axon formation, whereas multiple axons formed from a single neuron when GSK-3β activity was reduced by pharmacological inhibitors, a peptide inhibitor, or siRNAs. An active mechanism for maintaining neuronal polarity was revealed by the conversion of preexisting dendrites into axons upon GSK-3 inhibition. Biochemical and functional data show that the Akt kinase and the PTEN phosphatase are upstream of GSK-3β in determining neuronal polarity. Our results demonstrate that there are active mechanisms for maintaining as well as establishing neuronal polarity, indicate that GSK-3β relays signaling from Akt and PTEN to play critical roles in neuronal polarity, and suggest that application of GSK-3β inhibitors can be a novel approach to promote generation of new axons after neural injuries." @default.
- W2084080552 created "2016-06-24" @default.
- W2084080552 creator A5026528566 @default.
- W2084080552 creator A5031168904 @default.
- W2084080552 creator A5032865732 @default.
- W2084080552 creator A5032893114 @default.
- W2084080552 date "2005-01-01" @default.
- W2084080552 modified "2023-10-01" @default.
- W2084080552 title "Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms" @default.
- W2084080552 cites W1494495256 @default.
- W2084080552 cites W1518972222 @default.
- W2084080552 cites W1537624140 @default.
- W2084080552 cites W1564192489 @default.
- W2084080552 cites W1603204648 @default.
- W2084080552 cites W1701569822 @default.
- W2084080552 cites W1781370777 @default.
- W2084080552 cites W1897439129 @default.
- W2084080552 cites W1964935836 @default.
- W2084080552 cites W1972343960 @default.
- W2084080552 cites W1978679499 @default.
- W2084080552 cites W1982958012 @default.
- W2084080552 cites W1983055247 @default.
- W2084080552 cites W1987700551 @default.
- W2084080552 cites W1992423329 @default.
- W2084080552 cites W1993894835 @default.
- W2084080552 cites W1993940179 @default.
- W2084080552 cites W1997122736 @default.
- W2084080552 cites W1998276610 @default.
- W2084080552 cites W2001443225 @default.
- W2084080552 cites W2002897207 @default.
- W2084080552 cites W2005805156 @default.
- W2084080552 cites W2006376420 @default.
- W2084080552 cites W2010461127 @default.
- W2084080552 cites W2014531915 @default.
- W2084080552 cites W2017715649 @default.
- W2084080552 cites W2030102659 @default.
- W2084080552 cites W2031987855 @default.
- W2084080552 cites W2040942754 @default.
- W2084080552 cites W2049450589 @default.
- W2084080552 cites W2056220715 @default.
- W2084080552 cites W2058138221 @default.
- W2084080552 cites W2059346427 @default.
- W2084080552 cites W2061172411 @default.
- W2084080552 cites W2061414672 @default.
- W2084080552 cites W2062474690 @default.
- W2084080552 cites W2063120457 @default.
- W2084080552 cites W2065967745 @default.
- W2084080552 cites W2068427129 @default.
- W2084080552 cites W2070942270 @default.
- W2084080552 cites W2071433906 @default.
- W2084080552 cites W2072454482 @default.
- W2084080552 cites W2073128231 @default.
- W2084080552 cites W2074883812 @default.
- W2084080552 cites W2083739447 @default.
- W2084080552 cites W2091014617 @default.
- W2084080552 cites W2096222358 @default.
- W2084080552 cites W2103171833 @default.
- W2084080552 cites W2115136264 @default.
- W2084080552 cites W2129662130 @default.
- W2084080552 cites W2138070279 @default.
- W2084080552 cites W2921872615 @default.
- W2084080552 cites W4238839969 @default.
- W2084080552 cites W4376849538 @default.
- W2084080552 doi "https://doi.org/10.1016/j.cell.2004.12.033" @default.
- W2084080552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15652487" @default.
- W2084080552 hasPublicationYear "2005" @default.
- W2084080552 type Work @default.
- W2084080552 sameAs 2084080552 @default.
- W2084080552 citedByCount "223" @default.
- W2084080552 countsByYear W20840805522012 @default.
- W2084080552 countsByYear W20840805522013 @default.
- W2084080552 countsByYear W20840805522014 @default.
- W2084080552 countsByYear W20840805522015 @default.
- W2084080552 countsByYear W20840805522016 @default.
- W2084080552 countsByYear W20840805522017 @default.
- W2084080552 countsByYear W20840805522018 @default.
- W2084080552 countsByYear W20840805522019 @default.
- W2084080552 countsByYear W20840805522020 @default.
- W2084080552 countsByYear W20840805522021 @default.
- W2084080552 countsByYear W20840805522022 @default.
- W2084080552 countsByYear W20840805522023 @default.
- W2084080552 crossrefType "journal-article" @default.
- W2084080552 hasAuthorship W2084080552A5026528566 @default.
- W2084080552 hasAuthorship W2084080552A5031168904 @default.
- W2084080552 hasAuthorship W2084080552A5032865732 @default.
- W2084080552 hasAuthorship W2084080552A5032893114 @default.
- W2084080552 hasBestOaLocation W20840805521 @default.
- W2084080552 hasConcept C1491633281 @default.
- W2084080552 hasConcept C169760540 @default.
- W2084080552 hasConcept C182996813 @default.
- W2084080552 hasConcept C2777361361 @default.
- W2084080552 hasConcept C2777609662 @default.
- W2084080552 hasConcept C2778794669 @default.
- W2084080552 hasConcept C2779530196 @default.
- W2084080552 hasConcept C55493867 @default.
- W2084080552 hasConcept C62478195 @default.
- W2084080552 hasConcept C75217442 @default.
- W2084080552 hasConcept C86554907 @default.