FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084083234> ?p ?o ?g. }

• W2084083234 abstract "[4-[2-(1,1-Diphenylethylsulfanyl)-ethyl]-3,4-dihydro-2H-benzo[1,4]oxazin-8-yloxy]-acetic acid N-Methyl-d-glucamine salt (TRA-418) has both thromboxane A2 (TP)-receptor antagonist and prostacyclin (IP)-receptor agonist properties. The present study examined the advantageous effects of TRA-418 based on the dual activities, over an agent having either activity alone and also the difference in the effects of TRA-418 and a glycoprotein alphaIIb/beta3 integrin (GPIIb/IIIa) inhibitor. TRA-418 inhibited platelet GPIIb/IIIa activation as well as P-selectin expression induced by adenosine 5'-diphosphate, thrombin receptor agonist peptide 1-6 (Ser-Phe-Leu-Leu-Arg-Asn-NH2), and U-46619 in the presence of epinephrine (U-46619+ epinephrine). TRA-418 also inhibited platelet aggregation induced by those platelet-stimulants in Ca2+ chelating anticoagulant, citrate and in nonchelating anticoagulant, d-phenylalanyl-l-prolyl-l-arginyl-chloromethyl ketone (PPACK). The TP-receptor antagonist SQ-29548 inhibited only U-46619+epinephrine-induced GPIIb/IIIa activation, P-selectin expression, and platelet aggregation. The IP-receptor agonist beraprost sodium inhibited platelet activation. Beraprost also inhibited platelet aggregation induced by platelet stimulants we tested in citrate and in PPACK. The GPIIb/IIIa inhibitor abciximab blocked GPIIb/IIIa activation and platelet aggregation. However, abciximab showed slight inhibitory effects on P-selectin expression. TRA-418 is more advantageous as an antiplatelet agent than TP-receptor antagonists or IP-receptor agonists separately used. TRA-418 showed a different inhibitory profile from abciximab in the effects on P-selectin expression." @default.
• W2084083234 created "2016-06-24" @default.
• W2084083234 creator A5034504414 @default.
• W2084083234 creator A5038552383 @default.
• W2084083234 creator A5049297423 @default.
• W2084083234 creator A5055644244 @default.
• W2084083234 creator A5057548461 @default.
• W2084083234 creator A5078308263 @default.
• W2084083234 creator A5088804804 @default.
• W2084083234 date "2003-11-01" @default.
• W2084083234 modified "2023-10-06" @default.
• W2084083234 title "Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation" @default.
• W2084083234 cites W1568982528 @default.
• W2084083234 cites W1601529928 @default.
• W2084083234 cites W1901030926 @default.
• W2084083234 cites W1957982819 @default.
• W2084083234 cites W1965967389 @default.
• W2084083234 cites W1971354490 @default.
• W2084083234 cites W1993472744 @default.
• W2084083234 cites W2012166549 @default.
• W2084083234 cites W2018307163 @default.
• W2084083234 cites W2025651689 @default.
• W2084083234 cites W2045988801 @default.
• W2084083234 cites W2053917461 @default.
• W2084083234 cites W2057016253 @default.
• W2084083234 cites W2065194987 @default.
• W2084083234 cites W2079113645 @default.
• W2084083234 cites W2086270576 @default.
• W2084083234 cites W2097514615 @default.
• W2084083234 cites W2106264965 @default.
• W2084083234 cites W2122871792 @default.
• W2084083234 cites W2163007295 @default.
• W2084083234 cites W2165265464 @default.
• W2084083234 cites W2413471096 @default.
• W2084083234 cites W2416209319 @default.
• W2084083234 cites W2462760285 @default.
• W2084083234 cites W2610064544 @default.
• W2084083234 cites W4245860073 @default.
• W2084083234 cites W2096821978 @default.
• W2084083234 doi "https://doi.org/10.1038/sj.bjp.0705499" @default.
• W2084083234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1574093" @default.
• W2084083234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14504133" @default.
• W2084083234 hasPublicationYear "2003" @default.
• W2084083234 type Work @default.
• W2084083234 sameAs 2084083234 @default.
• W2084083234 citedByCount "9" @default.
• W2084083234 countsByYear W20840832342012 @default.
• W2084083234 crossrefType "journal-article" @default.
• W2084083234 hasAuthorship W2084083234A5034504414 @default.
• W2084083234 hasAuthorship W2084083234A5038552383 @default.
• W2084083234 hasAuthorship W2084083234A5049297423 @default.
• W2084083234 hasAuthorship W2084083234A5055644244 @default.
• W2084083234 hasAuthorship W2084083234A5057548461 @default.
• W2084083234 hasAuthorship W2084083234A5078308263 @default.
• W2084083234 hasAuthorship W2084083234A5088804804 @default.
• W2084083234 hasBestOaLocation W20840832342 @default.
• W2084083234 hasConcept C126322002 @default.
• W2084083234 hasConcept C170493617 @default.
• W2084083234 hasConcept C185592680 @default.
• W2084083234 hasConcept C26828662 @default.
• W2084083234 hasConcept C2776885963 @default.
• W2084083234 hasConcept C2777292125 @default.
• W2084083234 hasConcept C2777628954 @default.
• W2084083234 hasConcept C2778122271 @default.
• W2084083234 hasConcept C2778938600 @default.
• W2084083234 hasConcept C2781024287 @default.
• W2084083234 hasConcept C2909112448 @default.
• W2084083234 hasConcept C3018697912 @default.
• W2084083234 hasConcept C51603380 @default.
• W2084083234 hasConcept C55493867 @default.
• W2084083234 hasConcept C71924100 @default.
• W2084083234 hasConcept C89560881 @default.
• W2084083234 hasConcept C98274493 @default.
• W2084083234 hasConceptScore W2084083234C126322002 @default.
• W2084083234 hasConceptScore W2084083234C170493617 @default.
• W2084083234 hasConceptScore W2084083234C185592680 @default.
• W2084083234 hasConceptScore W2084083234C26828662 @default.
• W2084083234 hasConceptScore W2084083234C2776885963 @default.
• W2084083234 hasConceptScore W2084083234C2777292125 @default.
• W2084083234 hasConceptScore W2084083234C2777628954 @default.
• W2084083234 hasConceptScore W2084083234C2778122271 @default.
• W2084083234 hasConceptScore W2084083234C2778938600 @default.
• W2084083234 hasConceptScore W2084083234C2781024287 @default.
• W2084083234 hasConceptScore W2084083234C2909112448 @default.
• W2084083234 hasConceptScore W2084083234C3018697912 @default.
• W2084083234 hasConceptScore W2084083234C51603380 @default.
• W2084083234 hasConceptScore W2084083234C55493867 @default.
• W2084083234 hasConceptScore W2084083234C71924100 @default.
• W2084083234 hasConceptScore W2084083234C89560881 @default.
• W2084083234 hasConceptScore W2084083234C98274493 @default.
• W2084083234 hasLocation W20840832341 @default.
• W2084083234 hasLocation W20840832342 @default.
• W2084083234 hasLocation W20840832343 @default.
• W2084083234 hasLocation W20840832344 @default.
• W2084083234 hasOpenAccess W2084083234 @default.
• W2084083234 hasPrimaryLocation W20840832341 @default.
• W2084083234 hasRelatedWork W1566485786 @default.
• W2084083234 hasRelatedWork W167938242 @default.
• W2084083234 hasRelatedWork W1987799591 @default.
• W2084083234 hasRelatedWork W1988121084 @default.

• next