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- W2084085114 abstract "Angiogenesis is an important step in the complex biological and molecular events leading to successful healing of dermal wounds. Among the different cellular effectors of wound angiogenesis, the role of mesenchymal stem cells (MSCs) is of current interest due to their transdifferentiation and proangiogenic potentials. Skin is richly innervated by sympathetic nerves which secrete dopamine (DA) and we have recently shown that concentration of DA present in synaptic cleft can significantly inhibit wound tissue neovascularization. As recent reports indicate that MSCs by mobilizing into wound bed play an important role in promoting wound angiogenesis, we therefore investigated the effect of DA on the migration of MSCs in wound tissues. DA acted through its D2 receptors present in the MSCs to inhibit their mobilization to the wound beds by suppressing Akt phosphorylation and actin polymerization. In contrast, this inhibitory effect of DA was reversed after treatment with specific DA D2 receptor antagonist. Increased mobilization of MSCs was demonstrated in the wound site following blockade of DA D2 receptor mediated actions, and this in turn was associated with significantly more angiogenesis in wound tissues. This study is of translational value and indicates use of DA D2 receptor antagonists to stimulate mobilization of these stem cells for faster regeneration of damaged tissues." @default.
- W2084085114 created "2016-06-24" @default.
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- W2084085114 date "2012-02-15" @default.
- W2084085114 modified "2023-09-29" @default.
- W2084085114 title "Dopamine Regulates Mobilization of Mesenchymal Stem Cells during Wound Angiogenesis" @default.
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- W2084085114 doi "https://doi.org/10.1371/journal.pone.0031682" @default.
- W2084085114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280323" @default.
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